4ils: Difference between revisions

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'''Unreleased structure'''


The entry 4ils is ON HOLD  until sometime in the future
==Crystal structure of engineered protein. northeast structural genomics Consortium target or117==
 
<StructureSection load='4ils' size='340' side='right'caption='[[4ils]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
Authors: J. Seetharaman, Lew.S, Nivon. L, Baker.D, Bjelic. S, Ciccosanti. C, Sahdev. S, Xiao. R, Everett. J.K., Acton. T.B, Montelione. G.T, Tong.L, Hunt, J. F, Northeast Structural Genomics Consortium (NESG)
== Structural highlights ==
 
<table><tr><td colspan='2'>[[4ils]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ILS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ILS FirstGlance]. <br>
Description: CRYSTAL STRUCTURE OF ENGINEERED PROTEIN. NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET OR117
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ils FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ils OCA], [https://pdbe.org/4ils PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ils RCSB], [https://www.ebi.ac.uk/pdbsum/4ils PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ils ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ALR_GEOSE ALR_GEOSE] Catalyzes the interconversion of L-alanine and D-alanine. Also weakly active on serine.<ref>PMID:10502689</ref> <ref>PMID:12203980</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Acton TB]]
[[Category: Baker D]]
[[Category: Bjelic S]]
[[Category: Ciccosanti C]]
[[Category: Everett JK]]
[[Category: Hunt JF]]
[[Category: Lew S]]
[[Category: Montelione GT]]
[[Category: Nivon L]]
[[Category: Sahdev S]]
[[Category: Seetharaman J]]
[[Category: Tong L]]
[[Category: Xiao R]]

Latest revision as of 18:25, 20 September 2023

Crystal structure of engineered protein. northeast structural genomics Consortium target or117Crystal structure of engineered protein. northeast structural genomics Consortium target or117

Structural highlights

4ils is a 3 chain structure with sequence from Synthetic construct. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.5Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ALR_GEOSE Catalyzes the interconversion of L-alanine and D-alanine. Also weakly active on serine.[1] [2]

References

  1. ↑ Watanabe A, Yoshimura T, Mikami B, Esaki N. Tyrosine 265 of alanine racemase serves as a base abstracting alpha-hydrogen from L-alanine: the counterpart residue to lysine 39 specific to D-alanine. J Biochem. 1999 Oct;126(4):781-6. PMID:10502689
  2. ↑ Patrick WM, Weisner J, Blackburn JM. Site-directed mutagenesis of Tyr354 in Geobacillus stearothermophilus alanine racemase identifies a role in controlling substrate specificity and a possible role in the evolution of antibiotic resistance. Chembiochem. 2002 Aug 2;3(8):789-92. PMID:12203980 doi:<789::AID-CBIC789>3.0.CO;2-D http://dx.doi.org/10.1002/1439-7633(20020802)3:8<789::AID-CBIC789>3.0.CO;2-D

4ils, resolution 2.50Å

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