4idl: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
No edit summary |
||
| (3 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
==Low melting temperature Anti-Cholera Toxin Llama VHH domain== | ==Low melting temperature Anti-Cholera Toxin Llama VHH domain== | ||
<StructureSection load='4idl' size='340' side='right' caption='[[4idl]], [[Resolution|resolution]] 2.09Å' scene=''> | <StructureSection load='4idl' size='340' side='right'caption='[[4idl]], [[Resolution|resolution]] 2.09Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4idl]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4idl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IDL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IDL FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.09Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4idl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4idl OCA], [https://pdbe.org/4idl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4idl RCSB], [https://www.ebi.ac.uk/pdbsum/4idl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4idl ProSAT]</span></td></tr> | |||
</table> | </table> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
| Line 13: | Line 15: | ||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 4idl" style="background-color:#fffaf0;"></div> | |||
==See Also== | ==See Also== | ||
*[[Monoclonal | *[[Antibody 3D structures|Antibody 3D structures]] | ||
*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]] | |||
*[[3D structures of non-human antibody|3D structures of non-human antibody]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
| Line 21: | Line 26: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Lama glama]] | [[Category: Lama glama]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Hol WGJ]] | ||
[[Category: | [[Category: Lam A]] | ||
[[Category: | [[Category: Legler PM]] | ||
Latest revision as of 18:20, 20 September 2023
Low melting temperature Anti-Cholera Toxin Llama VHH domainLow melting temperature Anti-Cholera Toxin Llama VHH domain
Structural highlights
Publication Abstract from PubMedVariable heavy domains derived from the heavy-chain-only antibodies found in camelids (V(H)H domains) are known for their thermal stability. Here, the structure of A9, an anti-cholera toxin V(H)H domain (K(d) = 77 +/- 5 nM) that has an unusually low melting temperature of 319.9 +/- 1.6 K, is reported. The CDR3 residues of A9 form a beta-hairpin that is directed away from the former V(H)-V(L) interfacial surface, exposing hydrophobic residues to the solvent. A DALI structural similarity search showed that this CDR3 conformation is uncommon. Structure of a low-melting-temperature anti-cholera toxin: llama V(H)H domain.,Legler PM, Zabetakis D, Anderson GP, Lam A, Hol WG, Goldman ER Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Feb 1;69(Pt 2):90-3. doi: , 10.1107/S1744309112050750. Epub 2013 Jan 26. PMID:23385744[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
|
| ||||||||||||||||