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==Crystal Structure of New Delhi Metallo-beta-Lactamase-1, Complexed with Cd and Ampicillin==
==Crystal Structure of New Delhi Metallo-beta-Lactamase-1, Complexed with Cd and Ampicillin==
<StructureSection load='4hl1' size='340' side='right' caption='[[4hl1]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
<StructureSection load='4hl1' size='340' side='right'caption='[[4hl1]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4hl1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pneumoniae"_(schroeter_1886)_flugge_1886 "bacillus pneumoniae" (schroeter 1886) flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HL1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HL1 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4hl1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HL1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HL1 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZZ7:(2R,4S)-2-[(R)-{[(2R)-2-AMINO-2-PHENYLACETYL]AMINO}(CARBOXY)METHYL]-5,5-DIMETHYL-1,3-THIAZOLIDINE-4-CARBOXYLIC+ACID'>ZZ7</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3rkj|3rkj]], [[3rkk|3rkk]], [[3sbl|3sbl]], [[3sfp|3sfp]], [[3srx|3srx]], [[4gyq|4gyq]], [[4gyu|4gyu]], [[4h0d|4h0d]], [[4hky|4hky]], [[4hl2|4hl2]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZZ7:(2R,4S)-2-[(R)-{[(2R)-2-AMINO-2-PHENYLACETYL]AMINO}(CARBOXY)METHYL]-5,5-DIMETHYL-1,3-THIAZOLIDINE-4-CARBOXYLIC+ACID'>ZZ7</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">blaNDM-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=573 "Bacillus pneumoniae" (Schroeter 1886) Flugge 1886])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hl1 OCA], [https://pdbe.org/4hl1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hl1 RCSB], [https://www.ebi.ac.uk/pdbsum/4hl1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hl1 ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hl1 OCA], [http://pdbe.org/4hl1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hl1 RCSB], [http://www.ebi.ac.uk/pdbsum/4hl1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hl1 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/BLAN1_KLEPN BLAN1_KLEPN]] Confers resistance to many beta-lactam antibiotics, including some carbapenems. Does not confer resistance to the polymixin colistin or the fluoroquinolone ciprofloxacin.  
[https://www.uniprot.org/uniprot/BLAN1_KLEPN BLAN1_KLEPN] Confers resistance to many beta-lactam antibiotics, including some carbapenems. Does not confer resistance to the polymixin colistin or the fluoroquinolone ciprofloxacin.


==See Also==
==See Also==
*[[Beta-lactamase|Beta-lactamase]]
*[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Beta-lactamase]]
[[Category: Klebsiella pneumoniae]]
[[Category: Babnigg, J]]
[[Category: Large Structures]]
[[Category: Jedrzejczak, R]]
[[Category: Babnigg J]]
[[Category: Joachimiak, A]]
[[Category: Jedrzejczak R]]
[[Category: Kim, Y]]
[[Category: Joachimiak A]]
[[Category: Structural genomic]]
[[Category: Kim Y]]
[[Category: MTBI, Structures of Mtb Proteins Conferring Susceptibility to Known Mtb Inhibitors]]
[[Category: Mire J]]
[[Category: Mire, J]]
[[Category: Sacchettini J]]
[[Category: Sacchettini, J]]
[[Category: Tesar C]]
[[Category: Tesar, C]]
[[Category: Alpha-beta-beta-alpha sandwich]]
[[Category: Hydrolase]]
[[Category: Hydrolase-antibiotic complex]]
[[Category: Mcsg]]
[[Category: Mtbi]]
[[Category: Psi-biology]]
[[Category: Structures of mtb proteins conferring susceptibility to known mtb inhibitor]]

Latest revision as of 18:07, 20 September 2023

Crystal Structure of New Delhi Metallo-beta-Lactamase-1, Complexed with Cd and AmpicillinCrystal Structure of New Delhi Metallo-beta-Lactamase-1, Complexed with Cd and Ampicillin

Structural highlights

4hl1 is a 2 chain structure with sequence from Klebsiella pneumoniae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.5Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

BLAN1_KLEPN Confers resistance to many beta-lactam antibiotics, including some carbapenems. Does not confer resistance to the polymixin colistin or the fluoroquinolone ciprofloxacin.

See Also

4hl1, resolution 1.50Å

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