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==Crystal Structure of New Delhi Metallo-beta-Lactamase-1, Complexed with Cd and Ampicillin== | |||
<StructureSection load='4hl1' size='340' side='right'caption='[[4hl1]], [[Resolution|resolution]] 1.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4hl1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HL1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HL1 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZZ7:(2R,4S)-2-[(R)-{[(2R)-2-AMINO-2-PHENYLACETYL]AMINO}(CARBOXY)METHYL]-5,5-DIMETHYL-1,3-THIAZOLIDINE-4-CARBOXYLIC+ACID'>ZZ7</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hl1 OCA], [https://pdbe.org/4hl1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hl1 RCSB], [https://www.ebi.ac.uk/pdbsum/4hl1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hl1 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/BLAN1_KLEPN BLAN1_KLEPN] Confers resistance to many beta-lactam antibiotics, including some carbapenems. Does not confer resistance to the polymixin colistin or the fluoroquinolone ciprofloxacin. | |||
==See Also== | |||
*[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Klebsiella pneumoniae]] | |||
[[Category: Large Structures]] | |||
[[Category: Babnigg J]] | |||
[[Category: Jedrzejczak R]] | |||
[[Category: Joachimiak A]] | |||
[[Category: Kim Y]] | |||
[[Category: Mire J]] | |||
[[Category: Sacchettini J]] | |||
[[Category: Tesar C]] | |||
Latest revision as of 18:07, 20 September 2023
Crystal Structure of New Delhi Metallo-beta-Lactamase-1, Complexed with Cd and AmpicillinCrystal Structure of New Delhi Metallo-beta-Lactamase-1, Complexed with Cd and Ampicillin
Structural highlights
FunctionBLAN1_KLEPN Confers resistance to many beta-lactam antibiotics, including some carbapenems. Does not confer resistance to the polymixin colistin or the fluoroquinolone ciprofloxacin. See Also |
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