4hhf: Difference between revisions
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==Crystal Structure of chemically synthesized scorpion alpha-toxin OD1== | ==Crystal Structure of chemically synthesized scorpion alpha-toxin OD1== | ||
<StructureSection load='4hhf' size='340' side='right' caption='[[4hhf]], [[Resolution|resolution]] 1.80Å' scene=''> | <StructureSection load='4hhf' size='340' side='right'caption='[[4hhf]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4hhf]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HHF OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[4hhf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Odontobuthus_doriae Odontobuthus doriae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HHF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HHF FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hhf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hhf OCA], [https://pdbe.org/4hhf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hhf RCSB], [https://www.ebi.ac.uk/pdbsum/4hhf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hhf ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/SCX1_ODODO SCX1_ODODO] Alpha toxins bind voltage-independently at site-3 of sodium channels and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. Mammalian sodium channels Nav1.5/SCN2A (only at micromolar concentrations), Nav1.7/SCN9A (EC(50)=4.5 nM) and insect sodium channel para/tipE (EC(50)=80 nM) are affected by this toxin, whereas mammalian sodium channels Nav1.2/SCN2A, Nav1.3/SCN3A, and Nav1.8/SCN10A are unaffected by high concentrations.<ref>PMID:16038905</ref> <ref>PMID:16641312</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 4hhf" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Hemolysin 3D structures|Hemolysin 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Odontobuthus doriae]] | ||
[[Category: | [[Category: Alewood PF]] | ||
[[Category: | [[Category: Durek T]] | ||
[[Category: | [[Category: Lewis RJ]] | ||
[[Category: | [[Category: Wang CIA]] | ||