4hai: Difference between revisions

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 ==Crystal structure of human soluble epoxide hydrolase complexed with N-cycloheptyl-1-(mesitylsulfonyl)piperidine-4-carboxamide.==
-<StructureSection load='4hai' size='340' side='right' caption='[[4hai]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
+<StructureSection load='4hai' size='340' side='right'caption='[[4hai]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4hai]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HAI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HAI FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4hai]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HAI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HAI FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=I23:N-CYCLOHEPTYL-1-[(2,4,6-TRIMETHYLPHENYL)SULFONYL]PIPERIDINE-4-CARBOXAMIDE'>I23</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.55&#8491;</td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">EPHX2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=I23:N-CYCLOHEPTYL-1-[(2,4,6-TRIMETHYLPHENYL)SULFONYL]PIPERIDINE-4-CARBOXAMIDE'>I23</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hai FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hai OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hai RCSB], [http://www.ebi.ac.uk/pdbsum/4hai PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hai FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hai OCA], [https://pdbe.org/4hai PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hai RCSB], [https://www.ebi.ac.uk/pdbsum/4hai PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hai ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/HYES_HUMAN HYES_HUMAN] Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides. Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides. Also determines steady-state levels of physiological mediators. The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid, 12-phosphonooxy-octadec-9E-enoic acid, and p-nitrophenyl phospate.<ref>PMID:12574508</ref> <ref>PMID:12574510</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 15: / Line 18: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 4hai" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Epoxide hydrolase 3D structures|Epoxide hydrolase 3D structures]]
 == References ==
 <references/>
@@ Line 20: / Line 27: @@
 </StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Deng, S]]
+[[Category: Large Structures]]
-[[Category: Hammock, B D]]
+[[Category: Deng S]]
-[[Category: Morisseau, C]]
+[[Category: Hammock BD]]
-[[Category: Newcomer, M E]]
+[[Category: Morisseau C]]
-[[Category: Pakhomova, S]]
+[[Category: Newcomer ME]]
-[[Category: Pecic, S]]
+[[Category: Pakhomova S]]
-[[Category: Zhu, Z]]
+[[Category: Pecic S]]
-[[Category: Domain-swapped dimer]]
+[[Category: Zhu Z]]
-[[Category: Hydrolase-hydrolase inhibitor complex]]