4h7c: Difference between revisions

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 ==Crystal structure of human 17beta-hydroxysteroid dehydrogenase type 5 in complex with 1-{4-[(2-methyl-1-piperidinyl)sulfonyl]phenyl}-2-pyrrolidinone==
-<StructureSection load='4h7c' size='340' side='right' caption='[[4h7c]], [[Resolution|resolution]] 1.97&Aring;' scene=''>
+<StructureSection load='4h7c' size='340' side='right'caption='[[4h7c]], [[Resolution|resolution]] 1.97&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4h7c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H7C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4H7C FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4h7c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H7C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4H7C FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=10H:1-(4-{[(2R)-2-METHYLPIPERIDIN-1-YL]SULFONYL}PHENYL)-1,3-DIHYDRO-2H-PYRROL-2-ONE'>10H</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.97&#8491;</td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AKR1C3, DDH1, HSD17B5, KIAA0119, PGFS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=10H:1-(4-{[(2R)-2-METHYLPIPERIDIN-1-YL]SULFONYL}PHENYL)-1,3-DIHYDRO-2H-PYRROL-2-ONE'>10H</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4h7c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h7c OCA], [http://pdbe.org/4h7c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4h7c RCSB], [http://www.ebi.ac.uk/pdbsum/4h7c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4h7c ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4h7c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h7c OCA], [https://pdbe.org/4h7c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4h7c RCSB], [https://www.ebi.ac.uk/pdbsum/4h7c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4h7c ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/AK1C3_HUMAN AK1C3_HUMAN]] Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.
+[https://www.uniprot.org/uniprot/AK1C3_HUMAN AK1C3_HUMAN] Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 21: / Line 21: @@
 ==See Also==
-*[[Prostaglandin F synthase|Prostaglandin F synthase]]
+*[[Prostaglandin F synthase 3D structures|Prostaglandin F synthase 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
-[[Category: Denny, W A]]
+[[Category: Large Structures]]
-[[Category: Flanagan, J U]]
+[[Category: Denny WA]]
-[[Category: Heinrich, D]]
+[[Category: Flanagan JU]]
-[[Category: Jamieson, S M.F]]
+[[Category: Heinrich D]]
-[[Category: Owen, P J]]
+[[Category: Jamieson SMF]]
-[[Category: Raynham, T]]
+[[Category: Owen PJ]]
-[[Category: Rigoreau, L J.M]]
+[[Category: Raynham T]]
-[[Category: Samlal, S S]]
+[[Category: Rigoreau LJM]]
-[[Category: Schroeder, E]]
+[[Category: Samlal SS]]
-[[Category: Silva, S]]
+[[Category: Schroeder E]]
-[[Category: Soudy, C]]
+[[Category: Silva S]]
-[[Category: Trivier, E]]
+[[Category: Soudy C]]
-[[Category: Turnbull, A P]]
+[[Category: Trivier E]]
-[[Category: Aldo-keto reductase]]
+[[Category: Turnbull AP]]
-[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
-[[Category: Tim-barrel]]