4h33: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:4h33.jpg|left|200px]]
-{{STRUCTURE_4h33|  PDB=4h33  |  SCENE=  }}
+==Crystal structure of a voltage-gated K+ channel pore module in a closed state in lipid membranes, tetragonal crystal form==
+<StructureSection load='4h33' size='340' side='right'caption='[[4h33]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4h33]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Listeria_monocytogenes_EGD-e Listeria monocytogenes EGD-e]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H33 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4H33 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4h33 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h33 OCA], [https://pdbe.org/4h33 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4h33 RCSB], [https://www.ebi.ac.uk/pdbsum/4h33 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4h33 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q8Y5K1_LISMO Q8Y5K1_LISMO]
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Voltage-gated K(+) channels underlie the electrical excitability of cells. Each subunit of the functional tetramer consists of the tandem fusion of two modules, an N-terminal voltage-sensor and a C-terminal pore. To investigate how sensor coupling to the pore generates voltage-dependent channel opening, we solved the crystal structure and characterized the function of a voltage-gated K(+) channel pore in a lipid membrane. The structure of a functional channel in a membrane environment at 3.1 A resolution establishes an unprecedented connection between channel structure and function. The structure is unique in delineating an ion-occupied ready to conduct selectivity filter, a confined aqueous cavity, and a closed activation gate, embodying a dynamic entity trapped in an unstable closed state.
-===Crystal structure of a voltage-gated K+ channel pore module in a closed state in lipid membranes, tetragonal crystal form===
+Crystal Structure of a Voltage-gated K+ Channel Pore Module in a Closed State in Lipid Membranes.,Santos JS, Asmar-Rovira GA, Han GW, Liu W, Syeda R, Cherezov V, Baker KA, Stevens RC, Montal M J Biol Chem. 2012 Dec 14;287(51):43063-70. doi: 10.1074/jbc.M112.415091. Epub, 2012 Oct 24. PMID:23095758<ref>PMID:23095758</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-==About this Structure==
+</div>
-[[4h33]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Listeria_monocytogenes_egd-e Listeria monocytogenes egd-e]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H33 OCA].
+<div class="pdbe-citations 4h33" style="background-color:#fffaf0;"></div>
-[[Category: Listeria monocytogenes egd-e]]
+== References ==
-[[Category: Asmar-Rovira, G A.]]
+<references/>
-[[Category: Baker, K A.]]
+__TOC__
-[[Category: Cherezov, V.]]
+</StructureSection>
-[[Category: Han, G W.]]
+[[Category: Large Structures]]
-[[Category: Liu, W.]]
+[[Category: Listeria monocytogenes EGD-e]]
-[[Category: Montal, M.]]
+[[Category: Asmar-Rovira GA]]
-[[Category: Santos, J S.]]
+[[Category: Baker KA]]
-[[Category: Stevens, R C.]]
+[[Category: Cherezov V]]
-[[Category: Syeda, R.]]
+[[Category: Han GW]]
-[[Category: Bilayer]]
+[[Category: Liu W]]
-[[Category: Ion channel]]
+[[Category: Montal M]]
-[[Category: Kvlm]]
+[[Category: Santos JS]]
-[[Category: Membrane protein]]
+[[Category: Stevens RC]]
-[[Category: Pore module]]
+[[Category: Syeda R]]