Preprotein translocase: Difference between revisions

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<StructureSection load='2yxr' size='350' side='right' caption='Structure of preprotein translocase subunits SecY (grey), SecE (green), SecG (pink) (PDB entry [[2yxr]])' scene=''>
<StructureSection load='2yxr' size='350' side='right' caption='Structure of preprotein translocase subunits SecY (grey), SecE (green), SecG (pink) (PDB entry [[2yxr]])' scene=''>
== Function ==
== Function ==
'''Preprotein translocase''' (PPT) is responsible for the recognition and membrane translocation of preproteins.  PPT contains receptors and import motor.  The translocase pathway contains a chaperone protein – '''SecB'''; an integral membrane complex – '''SecY, SecE, SecG;''' proteins promoting the release of the mature peptide into the periplasm – '''SecD, SecF'''; and ATPase unit - '''SecA'''<ref>PMID:9489663</ref>. For more details see [[SecA PBD motions]].
'''Preprotein translocase''' (PPT) is responsible for the recognition and membrane translocation of preproteins.  PPT contains receptors and import motor<ref>PMID:9489663</ref>.  The translocase pathway contains:<br />
</StructureSection>
*'''SecB''' - a chaperone protein<ref>PMID:9767586</ref> <br />
*'''SecY, SecE, SecG''' or '''Sec61''' an integral membrane complex<br />
*'''SecD, SecF''' - proteins promoting the release of the mature peptide into the periplasm<br />
*'''SecA''' - an ATPase unit<ref>PMID:10617931</ref>.<br />
 
For more details see [[SecA PBD motions]].


==3D structures of preprotein translocase==
==3D structures of preprotein translocase==


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
[[Preprotein translocase 3D structures]]
{{#tree:id=OrganizedByTopic|openlevels=0|
 
*Preprotein translocase SecY + SecE + SecB
 
**[[1rh5]], [[1rhz]] – MjPPT SecY + SecE + SecB – ''Methanocaldococcus jannaschii'' <br />
 
*Preprotein translocase SecY + SecE + SecG
 
**[[2akh]], [[2aki]] – EcPPT SecY + SecE + SecG – ''Escherichia coli'' - CryoEM <br />
**[[2yxq]], [[2yxr]] – MjPPT SecY + SecE + SecG  <br />
**[[3dkn]] – PPT SecY + SecE + SecG + RNA – dog - CryoEM <br />
**[[3bo0]], [[3bo1]] – EcPPT SecY + SecE + SecG + 23S ribosomal RNA - CryoEM<br />
**[[3kcr]], [[3j45]], [[3j46]] – EcPPT SecY + SecE + SecG + large ribosomal subunit - CryoEM<br />
**[[1vvk]] – MjPPT SecY + SecE + SecG + large ribosomal subunit - CryoEM<br />
 
*Preprotein translocase SecY + SecE


**[[3mp7]] – PPT SecY + SecE – ''Pyrococcus furiosus''  <br />
**[[2zjs]] – TtPPT SecY + SecE + antibody – ''Thermus thermophilus''<br />
**[[2zqp]] – TtPPT SecY + SecE <br />
**[[3j01]] – EcPPT SecY + SecE + large ribosomal subunit - CryoEM<br />
*Preprotein translocase SecY + SecE + SecG + SecA
**[[3din]] – TmPPT SecY + SecE + SecG + SecA – ''Thermotoga maritima''<br />
**[[3dl8]] – PPT SecY + SecE + SecA + SecG – ''Aquifex aeolicus'' - CryoEM<br />
*Preprotein translocase SecA
**[[1m6n]], [[1tf5]], [[2ibm]] – BsPPT SecA – ''Bacillus subtilis'' <br />
**[[3iqm]], [[3iqy]] – BsPPT SecA (mutant)<br />
**[[1tm6]] – EcPPT SecA C terminal - NMR<br />
**[[2ipc]] – TtPPT SecA<br />
**[[3jux]] – TmPPT SecA<br />
**[[2fsf]] – EcPPT SecA<br />
**[[2fsf]] – EcPPT SecA<br />
**[[3bxz]] – EcPPT SecA dead motor domains (mutant)<br />
**[[1nl3]] – MtPPT SecA – ''Mycobacterium tuberculosis''<br />
*Preprotein translocase SecA complex
**[[1m74]], [[1tf2]] – BsPPT SecA + Mg + ADP  <br />
**[[1ozb]] – PPT SecA C terminal + SecB  - ''Haemophilus influenzae''<br />
**[[2fsh]] – EcPPT SecA + AMPPNP<br />
**[[2fsi]] – EcPPT SecA + ADP<br />
**[[2fsg]] – EcPPT SecA + ATP<br />
**[[2vda]] – EcPPT SecA + maltoporin signal peptide - NMR<br />
**[[3jv2]] – BsPPT SecA + peptide <br />
**[[1nkt]] – MtPPT SecA + ADP<br />
}}
== References ==
== References ==
<references/>
<references/>
</StructureSection>
[[Category:Topic Page]]
[[Category:Topic Page]]

Latest revision as of 10:33, 12 September 2023

Function

Preprotein translocase (PPT) is responsible for the recognition and membrane translocation of preproteins. PPT contains receptors and import motor[1]. The translocase pathway contains:

  • SecB - a chaperone protein[2]
  • SecY, SecE, SecG or Sec61 an integral membrane complex
  • SecD, SecF - proteins promoting the release of the mature peptide into the periplasm
  • SecA - an ATPase unit[3].

For more details see SecA PBD motions.

3D structures of preprotein translocase

Preprotein translocase 3D structures

References

  1. ↑ Economou A. Bacterial preprotein translocase: mechanism and conformational dynamics of a processive enzyme. Mol Microbiol. 1998 Feb;27(3):511-8. PMID:9489663
  2. ↑ Fekkes P, de Wit JG, van der Wolk JP, Kimsey HH, Kumamoto CA, Driessen AJ. Preprotein transfer to the Escherichia coli translocase requires the co-operative binding of SecB and the signal sequence to SecA. Mol Microbiol. 1998 Sep;29(5):1179-90. PMID:9767586
  3. ↑ Schmidt MG, Kiser KB. SecA: the ubiquitous component of preprotein translocase in prokaryotes. Microbes Infect. 1999 Oct;1(12):993-1004. PMID:10617931

Structure of preprotein translocase subunits SecY (grey), SecE (green), SecG (pink) (PDB entry 2yxr)

Drag the structure with the mouse to rotate

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Michal Harel, Alexander Berchansky
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