Preprotein translocase: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

@@ Line 1: / Line 1: @@
 <StructureSection load='2yxr' size='350' side='right' caption='Structure of preprotein translocase subunits SecY (grey), SecE (green), SecG (pink) (PDB entry [[2yxr]])' scene=''>
+== Function ==
+'''Preprotein translocase''' (PPT) is responsible for the recognition and membrane translocation of preproteins.  PPT contains receptors and import motor<ref>PMID:9489663</ref>.  The translocase pathway contains:<br />
+*'''SecB''' - a chaperone protein<ref>PMID:9767586</ref> <br />
+*'''SecY, SecE, SecG''' or '''Sec61''' an integral membrane complex<br />
+*'''SecD, SecF''' - proteins promoting the release of the mature peptide into the periplasm<br />
+*'''SecA''' - an ATPase unit<ref>PMID:10617931</ref>.<br />
-'''Preprotein translocase''' (PPT) is responsible for the recognition and membrane translocation of preproteins.  PPT contains receptors and import motor.  The translocase pathway contains a chaperone protein – '''SecB'''; an integral membrane complex – '''SecY, SecE, SecG;''' proteins promoting the release of the mature peptide into the periplasm – '''SecD, SecF'''; and ATPase unit - '''SecA'''.  For more details see [[SecA PBD motions]].
+For more details see [[SecA PBD motions]].
 ==3D structures of preprotein translocase==
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+[[Preprotein translocase 3D structures]]
-{{#tree:id=OrganizedByTopic|openlevels=0|
-*Preprotein translocase SecY + SecE + SecB
+== References ==
+<references/>
+</StructureSection>
-**[[1rh5]], [[1rhz]] – MjPPT SecY + SecE + SecB – ''Methanocaldococcus jannaschii'' <br />
-*Preprotein translocase SecY + SecE + SecG
-**[[2akh]], [[2aki]] – EcPPT SecY + SecE + SecG – ''Escherichia coli'' - CryoEM <br />
-**[[2yxq]], [[2yxr]] – MjPPT SecY + SecE + SecG  <br />
-**[[3dkn]] – PPT SecY + SecE + SecG + RNA – dog - CryoEM <br />
-**[[3bo0]], [[3bo1]] – EcPPT SecY + SecE + SecG + 23S ribosomal RNA - CryoEM<br />
-**[[3kcr]], [[3j45]], [[3j46]] – EcPPT SecY + SecE + SecG + large ribosomal subunit - CryoEM<br />
-**[[1vvk]] – MjPPT SecY + SecE + SecG + large ribosomal subunit - CryoEM<br />
-*Preprotein translocase SecY + SecE
-**[[3mp7]] – PPT SecY + SecE – ''Pyrococcus furiosus''  <br />
-**[[2zjs]] – TtPPT SecY + SecE + antibody – ''Thermus thermophilus''<br />
-**[[2zqp]] – TtPPT SecY + SecE <br />
-**[[3j01]] – EcPPT SecY + SecE + large ribosomal subunit - CryoEM<br />
-*Preprotein translocase SecY + SecE + SecG + SecA
-**[[3din]] – TmPPT SecY + SecE + SecG + SecA – ''Thermotoga maritima''<br />
-**[[3dl8]] – PPT SecY + SecE + SecA + SecG – ''Aquifex aeolicus'' - CryoEM<br />
-*Preprotein translocase SecA
-**[[1m6n]], [[1tf5]], [[2ibm]] – BsPPT SecA – ''Bacillus subtilis'' <br />
-**[[3iqm]], [[3iqy]] – BsPPT SecA (mutant)<br />
-**[[1tm6]] – EcPPT SecA C terminal - NMR<br />
-**[[2ipc]] – TtPPT SecA<br />
-**[[3jux]] – TmPPT SecA<br />
-**[[2fsf]] – EcPPT SecA<br />
-**[[2fsf]] – EcPPT SecA<br />
-**[[3bxz]] – EcPPT SecA dead motor domains (mutant)<br />
-**[[1nl3]] – MtPPT SecA – ''Mycobacterium tuberculosis''<br />
-*Preprotein translocase SecA complex
-**[[1m74]], [[1tf2]] – BsPPT SecA + Mg + ADP  <br />
-**[[1ozb]] – PPT SecA C terminal + SecB  - ''Haemophilus influenzae''<br />
-**[[2fsh]] – EcPPT SecA + AMPPNP<br />
-**[[2fsi]] – EcPPT SecA + ADP<br />
-**[[2fsg]] – EcPPT SecA + ATP<br />
-**[[2vda]] – EcPPT SecA + maltoporin signal peptide - NMR<br />
-**[[3jv2]] – BsPPT SecA + peptide <br />
-**[[1nkt]] – MtPPT SecA + ADP<br />
-}}
 [[Category:Topic Page]]