5j0d: Difference between revisions

<StructureSection load='5j0d' size='340' side='right'caption='[[5j0d]], [[Resolution|resolution]] 1.05&Aring;' scene=''>

<table><tr><td colspan='2'>[[5j0d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J0D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5J0D FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.05&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6F9:7-(3,5-DIMETHOXYPHENYL)-N-[(3S)-1-METHYLPIPERIDIN-3-YL]-4-PROPANOYL-2,3,4,5-TETRAHYDRO-1,4-BENZOXAZEPINE-9-CARBOXAMIDE'>6F9</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5j0d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j0d OCA], [https://pdbe.org/5j0d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5j0d RCSB], [https://www.ebi.ac.uk/pdbsum/5j0d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5j0d ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/CBP_HUMAN CBP_HUMAN] Note=Chromosomal aberrations involving CREBBP may be a cause of acute myeloid leukemias. Translocation t(8;16)(p11;p13) with KAT6A; translocation t(11;16)(q23;p13.3) with MLL/HRX; translocation t(10;16)(q22;p13) with KAT6B. KAT6A-CREBBP may induce leukemia by inhibiting RUNX1-mediated transcription.  Defects in CREBBP are a cause of Rubinstein-Taybi syndrome type 1 (RSTS1) [MIM:[https://omim.org/entry/180849 180849]. RSTS1 is an autosomal dominant disorder characterized by craniofacial abnormalities, broad thumbs, broad big toes, mental retardation and a propensity for development of malignancies.<ref>PMID:11331617</ref> <ref>PMID:12114483</ref> <ref>PMID:12566391</ref> <ref>PMID:15706485</ref>  

[https://www.uniprot.org/uniprot/CBP_HUMAN CBP_HUMAN] Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300.<ref>PMID:9707565</ref> <ref>PMID:11154691</ref> <ref>PMID:12738767</ref> <ref>PMID:12929931</ref>  

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Arrowsmith CH]]

[[Category: Bountra C]]

[[Category: Bracher F]]

[[Category: Edwards AM]]

[[Category: Fedorov O]]

[[Category: Knapp S]]

[[Category: Picaud S]]

[[Category: Popp TA]]

[[Category: Siejka P]]

[[Category: Tallant C]]

[[Category: Von Delft F]]