5ixc: Difference between revisions

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==Human GIVD cytosolic phospholipase A2 in complex with Methyl gamma-Linolenyl Fluorophosphonate==
==Human GIVD cytosolic phospholipase A2 in complex with Methyl gamma-Linolenyl Fluorophosphonate==
<StructureSection load='5ixc' size='340' side='right' caption='[[5ixc]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
<StructureSection load='5ixc' size='340' side='right'caption='[[5ixc]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5ixc]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IXC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IXC FirstGlance]. <br>
<table><tr><td colspan='2'>[[5ixc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IXC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5IXC FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7FA:METHYL+(R)-(6Z,9Z,12Z)-OCTADECA-6,9,12-TRIEN-1-YLPHOSPHONOFLUORIDATE'>7FA</scene>, <scene name='pdbligand=BA:BARIUM+ION'>BA</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5iz5|5iz5]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7FA:METHYL+(R)-(6Z,9Z,12Z)-OCTADECA-6,9,12-TRIEN-1-YLPHOSPHONOFLUORIDATE'>7FA</scene>, <scene name='pdbligand=BA:BARIUM+ION'>BA</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ixc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ixc OCA], [https://pdbe.org/5ixc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ixc RCSB], [https://www.ebi.ac.uk/pdbsum/5ixc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ixc ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ixc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ixc OCA], [http://pdbe.org/5ixc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ixc RCSB], [http://www.ebi.ac.uk/pdbsum/5ixc PDBsum]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PA24D_HUMAN PA24D_HUMAN]] Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. Not arachidonic acid-specific but has linoleic acid-specific activity. May play a role in inflammation in psoriatic lesions.<ref>PMID:14709560</ref>
[https://www.uniprot.org/uniprot/PA24D_HUMAN PA24D_HUMAN] Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. Not arachidonic acid-specific but has linoleic acid-specific activity. May play a role in inflammation in psoriatic lesions.<ref>PMID:14709560</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5ixc" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5ixc" style="background-color:#fffaf0;"></div>
==See Also==
*[[Phospholipase A2 3D structures|Phospholipase A2 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Klein, M G]]
[[Category: Homo sapiens]]
[[Category: Wang, H]]
[[Category: Large Structures]]
[[Category: Alpha/beta hydrolase]]
[[Category: Klein MG]]
[[Category: C2 domain]]
[[Category: Wang H]]
[[Category: Calcium binding]]
[[Category: Hydrolase]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Inhibitor]]
[[Category: Phospholipase]]
[[Category: Signal transduction]]

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