3peq: Difference between revisions

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 ==PPARd complexed with a phenoxyacetic acid partial agonist==
-<StructureSection load='3peq' size='340' side='right' caption='[[3peq]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
+<StructureSection load='3peq' size='340' side='right'caption='[[3peq]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[3peq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PEQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PEQ FirstGlance]. <br>
+<table><tr><td colspan='2'>[[3peq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PEQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PEQ FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3EQ:[(4-{BUTYL[2-METHYL-4-(METHYLSULFANYL)BIPHENYL-3-YL]SULFAMOYL}NAPHTHALEN-1-YL)OXY]ACETIC+ACID'>3EQ</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=JZR:HEXYL+BETA-D-GLUCOPYRANOSIDE'>JZR</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NR1C2, PPARB, PPARD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3EQ:[(4-{BUTYL[2-METHYL-4-(METHYLSULFANYL)BIPHENYL-3-YL]SULFAMOYL}NAPHTHALEN-1-YL)OXY]ACETIC+ACID'>3EQ</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=JZR:HEXYL+BETA-D-GLUCOPYRANOSIDE'>JZR</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3peq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3peq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3peq RCSB], [http://www.ebi.ac.uk/pdbsum/3peq PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3peq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3peq OCA], [https://pdbe.org/3peq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3peq RCSB], [https://www.ebi.ac.uk/pdbsum/3peq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3peq ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/PPARD_HUMAN PPARD_HUMAN] Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.<ref>PMID:1333051</ref> <ref>PMID:15604518</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 15: / Line 18: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 3peq" style="background-color:#fffaf0;"></div>
 ==See Also==
-*[[Peroxisome Proliferator-Activated Receptors|Peroxisome Proliferator-Activated Receptors]]
+*[[Peroxisome proliferator-activated receptor 3D structures|Peroxisome proliferator-activated receptor 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
-[[Category: Billin, A N.]]
+[[Category: Large Structures]]
-[[Category: Britt, C.]]
+[[Category: Billin AN]]
-[[Category: Evans, K A.]]
+[[Category: Britt C]]
-[[Category: Jin, J.]]
+[[Category: Evans KA]]
-[[Category: Lambert, M H.]]
+[[Category: Jin J]]
-[[Category: Leesnitzer, L M.]]
+[[Category: Lambert MH]]
-[[Category: Merrihew, R V.]]
+[[Category: Leesnitzer LM]]
-[[Category: Rivero, R A.]]
+[[Category: Merrihew RV]]
-[[Category: Shearer, B G.]]
+[[Category: Rivero RA]]
-[[Category: Shi, D.]]
+[[Category: Shearer BG]]
-[[Category: Sparks, S M.]]
+[[Category: Shi D]]
-[[Category: Way, J M.]]
+[[Category: Sparks SM]]
-[[Category: Winegar, D A.]]
+[[Category: Way JM]]
-[[Category: Wisnoski, D D.]]
+[[Category: Winegar DA]]
-[[Category: Ppar nuclear receptor]]
+[[Category: Wisnoski DD]]
-[[Category: Transcription-transcription agonist complex]]