3peq: Difference between revisions
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==PPARd complexed with a phenoxyacetic acid partial agonist== | |||
<StructureSection load='3peq' size='340' side='right'caption='[[3peq]], [[Resolution|resolution]] 2.40Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3peq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PEQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PEQ FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3EQ:[(4-{BUTYL[2-METHYL-4-(METHYLSULFANYL)BIPHENYL-3-YL]SULFAMOYL}NAPHTHALEN-1-YL)OXY]ACETIC+ACID'>3EQ</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=JZR:HEXYL+BETA-D-GLUCOPYRANOSIDE'>JZR</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3peq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3peq OCA], [https://pdbe.org/3peq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3peq RCSB], [https://www.ebi.ac.uk/pdbsum/3peq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3peq ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/PPARD_HUMAN PPARD_HUMAN] Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.<ref>PMID:1333051</ref> <ref>PMID:15604518</ref> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
A series of phenoxyacetic acids as subtype selective and potent hPPARdelta partial agonists is described. Many analogues were readily accessible via a single solution-phase synthetic route which resulted in the rapid identification of key structure-activity relationships (SAR), and the discovery of two potent exemplars which were further evaluated in vivo. Details of the SAR, optimization, and in vivo efficacy of this series are presented herein. | |||
Phenoxyacetic acids as PPARdelta partial agonists: synthesis, optimization, and in vivo efficacy.,Evans KA, Shearer BG, Wisnoski DD, Shi D, Sparks SM, Sternbach DD, Winegar DA, Billin AN, Britt C, Way JM, Epperly AH, Leesnitzer LM, Merrihew RV, Xu RX, Lambert MH, Jin J Bioorg Med Chem Lett. 2011 Apr 15;21(8):2345-50. Epub 2011 Mar 15. PMID:21414782<ref>PMID:21414782</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 3peq" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Peroxisome proliferator-activated receptor 3D structures|Peroxisome proliferator-activated receptor 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Billin AN]] | |||
[[Category: Britt C]] | |||
[[Category: Evans KA]] | |||
[[Category: Jin J]] | |||
[[Category: Lambert MH]] | |||
[[Category: Leesnitzer LM]] | |||
[[Category: Merrihew RV]] | |||
[[Category: Rivero RA]] | |||
[[Category: Shearer BG]] | |||
[[Category: Shi D]] | |||
[[Category: Sparks SM]] | |||
[[Category: Way JM]] | |||
[[Category: Winegar DA]] | |||
[[Category: Wisnoski DD]] | |||