3og6: Difference between revisions

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-[[Image:3og6.png|left|200px]]
-{{STRUCTURE_3og6|  PDB=3og6  |  SCENE=  }}
+==The crystal structure of human interferon lambda 1 complexed with its high affinity receptor in space group P212121==
+<StructureSection load='3og6' size='340' side='right'caption='[[3og6]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3og6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OG6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OG6 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.097&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3og6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3og6 OCA], [https://pdbe.org/3og6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3og6 RCSB], [https://www.ebi.ac.uk/pdbsum/3og6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3og6 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/IFNL1_HUMAN IFNL1_HUMAN] Cytokine with immunomodulatory activity. May play a role in antiviral immunity. Up-regulates MHC class I antigen expression. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1. The ligand/receptor complex seems to signal through the Jak-STAT pathway.
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Interferon (IFN)-lambda1 [also known as interleukin (IL)-29] belongs to the recently discovered group of type III IFNs. All type III IFNs initiate signaling processes through formation of specific heterodimeric receptor complexes consisting of IFN-lambdaR1 and IL-10R2. We have determined the structure of human IFN-lambda1 complexed with human IFN-lambdaR1, a receptor unique to type III IFNs. The overall structure of IFN-lambda1 is topologically similar to the structure of IL-10 and other members of the IL-10 family of cytokines. IFN-lambdaR1 consists of two distinct domains having fibronectin type III topology. The ligand-receptor interface includes helix A, loop AB, and helix F on the IFN site, as well as loops primarily from the N-terminal domain and inter-domain hinge region of IFN-lambdaR1. Composition and architecture of the interface that includes only a few direct hydrogen bonds support an idea that long-range ionic interactions between ligand and receptor govern the process of initial recognition of the molecules while hydrophobic interactions finalize it.
-===The crystal structure of human interferon lambda 1 complexed with its high affinity receptor in space group P212121===
+Crystal Structure of Human Interferon-lambda1 in Complex with Its High-Affinity Receptor Interferon-lambdaR1.,Miknis Z, Magracheva E, Li W, Zdanov A, Kotenko SV, Wlodawer A J Mol Biol. 2010 Oct 8. PMID:20934432<ref>PMID:20934432</ref>
-{{ABSTRACT_PUBMED_20934432}}
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-==About this Structure==
+<div class="pdbe-citations 3og6" style="background-color:#fffaf0;"></div>
-[[3og6]] is a 2 chain structure of [[Interleukin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OG6 OCA].
 ==See Also==
-*[[Interleukin|Interleukin]]
+*[[Interferon 3D structures|Interferon 3D structures]]
+*[[Interferon receptor 3D structures|Interferon receptor 3D structures]]
-==Reference==
+*[[Interleukin 3D structures|Interleukin 3D structures]]
-<ref group="xtra">PMID:020934432</ref><references group="xtra"/>
+*[[Interleukin receptor 3D structures|Interleukin receptor 3D structures]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Kotenko, S V.]]
+[[Category: Large Structures]]
-[[Category: Lei, W.]]
+[[Category: Kotenko SV]]
-[[Category: Magracheva, E.]]
+[[Category: Lei W]]
-[[Category: Miknis, Z J.]]
+[[Category: Magracheva E]]
-[[Category: Wlodawer, A.]]
+[[Category: Miknis ZJ]]
-[[Category: Zdanov, A.]]
+[[Category: Wlodawer A]]
-[[Category: Beta-sandwich]]
+[[Category: Zdanov A]]
-[[Category: Cytokine signaling]]
-[[Category: Cytokine-cytokine receptor complex]]
-[[Category: Fibronectin type iii domain]]
-[[Category: Helical bundle]]
-[[Category: Membrane]]