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==Crystal Structure of the DH/PH Domains of p115-RhoGEF== | ==Crystal Structure of the DH/PH Domains of p115-RhoGEF== | ||
<StructureSection load='3odo' size='340' side='right' caption='[[3odo]], [[Resolution|resolution]] 2.90Å' scene=''> | <StructureSection load='3odo' size='340' side='right'caption='[[3odo]], [[Resolution|resolution]] 2.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3odo]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[3odo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ODO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ODO FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3odo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3odo OCA], [https://pdbe.org/3odo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3odo RCSB], [https://www.ebi.ac.uk/pdbsum/3odo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3odo ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/ARHG1_HUMAN ARHG1_HUMAN] Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation.<ref>PMID:8810315</ref> <ref>PMID:9641915</ref> <ref>PMID:9641916</ref> <ref>PMID:20098430</ref> | |||
==See Also== | |||
*[[Rho guanine nucleotide exchange factor 3D structures|Rho guanine nucleotide exchange factor 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Chen Z]] | ||
[[Category: | [[Category: Guo L]] | ||
[[Category: | [[Category: Sprang SR]] | ||
[[Category: | [[Category: Sternweis PC]] | ||