3o88: Difference between revisions

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==Crystal structure of AmpC beta-lactamase in complex with a sulfonamide boronic acid inhibitor==
==Crystal structure of AmpC beta-lactamase in complex with a sulfonamide boronic acid inhibitor==
<StructureSection load='3o88' size='340' side='right' caption='[[3o88]], [[Resolution|resolution]] 1.64&Aring;' scene=''>
<StructureSection load='3o88' size='340' side='right'caption='[[3o88]], [[Resolution|resolution]] 1.64&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3o88]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O88 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3O88 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3o88]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O88 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3O88 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BSH:3-[(2R)-2-[(BENZYLSULFONYL)AMINO]-2-(DIHYDROXYBORANYL)ETHYL]BENZOIC+ACID'>BSH</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.64&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3o86|3o86]], [[3o87|3o87]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BSH:3-[(2R)-2-[(BENZYLSULFONYL)AMINO]-2-(DIHYDROXYBORANYL)ETHYL]BENZOIC+ACID'>BSH</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ampA, ampC, b4150, JW4111 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3o88 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o88 OCA], [https://pdbe.org/3o88 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3o88 RCSB], [https://www.ebi.ac.uk/pdbsum/3o88 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3o88 ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3o88 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o88 OCA], [http://pdbe.org/3o88 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3o88 RCSB], [http://www.ebi.ac.uk/pdbsum/3o88 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3o88 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/AMPC_ECOLI AMPC_ECOLI]] This protein is a serine beta-lactamase with a substrate specificity for cephalosporins.  
[https://www.uniprot.org/uniprot/AMPC_ECOLI AMPC_ECOLI] This protein is a serine beta-lactamase with a substrate specificity for cephalosporins.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Beta-lactamase|Beta-lactamase]]
*[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Beta-lactamase]]
[[Category: Escherichia coli K-12]]
[[Category: Ecoli]]
[[Category: Large Structures]]
[[Category: Eidam, O]]
[[Category: Eidam O]]
[[Category: Karpiak, J]]
[[Category: Karpiak J]]
[[Category: Romagnoli, C]]
[[Category: Romagnoli C]]
[[Category: Shoichet, B K]]
[[Category: Shoichet BK]]
[[Category: Cephalosporinase]]
[[Category: Class c]]
[[Category: Contains alpha helices and a beta sandwich / beta-lactamase-like fold / ampc beta-lactamase]]
[[Category: Hydrolase]]

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