3nr9: Difference between revisions

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-[[Image:3nr9.png|left|200px]]
-{{STRUCTURE_3nr9|  PDB=3nr9  |  SCENE=  }}
+==Structure of human CDC2-like kinase 2 (CLK2)==
+<StructureSection load='3nr9' size='340' side='right'caption='[[3nr9]], [[Resolution|resolution]] 2.89&Aring;' scene=''>
-===Structure of human CDC2-like kinase 2 (CLK2)===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3nr9]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NR9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NR9 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.89&#8491;</td></tr>
-==About this Structure==
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NR9:(5Z)-5-(QUINOLIN-6-YLMETHYLIDENE)-2-[(THIOPHEN-2-YLMETHYL)AMINO]-1,3-THIAZOL-4(5H)-ONE'>NR9</scene></td></tr>
-[[3nr9]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NR9 OCA].
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nr9 OCA], [https://pdbe.org/3nr9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nr9 RCSB], [https://www.ebi.ac.uk/pdbsum/3nr9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nr9 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/CLK2_HUMAN CLK2_HUMAN] Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. Phosphorylates: PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.<ref>PMID:10480872</ref> <ref>PMID:19168442</ref> <ref>PMID:8910305</ref> <ref>PMID:9637771</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nr/3nr9_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3nr9 ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Dual specificity protein kinase|Dual specificity protein kinase]]
+*[[Dual specificity protein kinase 3D structures|Dual specificity protein kinase 3D structures]]
-[[Category: Dual-specificity kinase]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Arrowsmith, C H.]]
+[[Category: Large Structures]]
-[[Category: Berridge, G.]]
+[[Category: Arrowsmith CH]]
-[[Category: Bountra, C.]]
+[[Category: Berridge G]]
-[[Category: Chaikuad, A.]]
+[[Category: Bountra C]]
-[[Category: Delft, F von.]]
+[[Category: Chaikuad A]]
-[[Category: Edwards, A M.]]
+[[Category: Edwards AM]]
-[[Category: Eswaran, J.]]
+[[Category: Eswaran J]]
-[[Category: Fedorov, O.]]
+[[Category: Fedorov O]]
-[[Category: Filippakopoulos, P.]]
+[[Category: Filippakopoulos P]]
-[[Category: Keates, T.]]
+[[Category: Keates T]]
-[[Category: Knapp, S.]]
+[[Category: Knapp S]]
-[[Category: Krojer, T.]]
+[[Category: Krojer T]]
-[[Category: Muniz, J R.C.]]
+[[Category: Muniz JRC]]
-[[Category: Phillips, C.]]
+[[Category: Phillips C]]
-[[Category: Pike, A C.W.]]
+[[Category: Pike ACW]]
-[[Category: Rellos, P.]]
+[[Category: Rellos P]]
-[[Category: SGC, Structural Genomics Consortium.]]
+[[Category: Savitsky P]]
-[[Category: Savitsky, P.]]
+[[Category: Weigelt J]]
-[[Category: Weigelt, J.]]
+[[Category: Zhang Y]]
-[[Category: Zhang, Y.]]
+[[Category: Von Delft F]]
-[[Category: Dual specificity protein kinase]]
-[[Category: Protein kinase]]
-[[Category: Sgc]]
-[[Category: Structural genomics consortium]]
-[[Category: Transferase]]