3ndv: Difference between revisions

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OCA

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-'''Unreleased structure'''
-The entry 3ndv is ON HOLD
+==Crystal structure of the N-terminal beta-aminopeptidase BapA in complex with ampicillin==
+<StructureSection load='3ndv' size='340' side='right'caption='[[3ndv]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3ndv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Sphingosinicella_xenopeptidilytica Sphingosinicella xenopeptidilytica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NDV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NDV FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AIC:(2S,5R,6R)-6-{[(2R)-2-AMINO-2-PHENYLETHANOYL]AMINO}-3,3-DIMETHYL-7-OXO-4-THIA-1-AZABICYCLO[3.2.0]HEPTANE-2-CARBOXYLIC+ACID'>AIC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NDV:(2S,4S)-2-[(1R)-1-{[(2R)-2-AMINO-2-PHENYLACETYL]AMINO}-2-OXOETHYL]-5,5-DIMETHYL-1,3-THIAZOLIDINE-4-CARBOXYLIC+ACID'>NDV</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ndv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ndv OCA], [https://pdbe.org/3ndv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ndv RCSB], [https://www.ebi.ac.uk/pdbsum/3ndv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ndv ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/BAPA_SPHXN BAPA_SPHXN] Beta-aminopeptidase that can cleave synthetic beta-peptides which consist of backbone-elongated beta-amino acid residues that are not processed by common proteolytic enzymes. Can cleave the beta-peptides beta-homoVal-beta-homoAla-beta-homoLeu and beta-homoAla-beta-homoLeu. Requires a beta-amino acid at the N-terminus of peptide substrates and cleaves the peptide bond between the N-terminal beta-amino acid and the amino acid at the second position of tripeptidic substrates of the general structure H-betahXaa-Ile-betahTyr-OH according to the following preferences with regard to the side chain of the N-terminal beta-amino acid: aliphatic and aromatic > OH-containing > hydrogen, basic and polar.<ref>PMID:16109932</ref> <ref>PMID:17064315</ref>
-Authors: Merz, T., Heck, T., Geueke, B., Kohler, H.-P.E., Gruetter, M.G.
+==See Also==
+*[[Aminopeptidase 3D structures|Aminopeptidase 3D structures]]
-Description: Crystal structure of the N-terminal beta-aminopeptidase BapA in complex with ampicillin (CASP Target)
+== References ==
+<references/>
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 16 08:30:36 2010''
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Sphingosinicella xenopeptidilytica]]
+[[Category: Geueke B]]
+[[Category: Gruetter MG]]
+[[Category: Heck T]]
+[[Category: Kohler H-PE]]
+[[Category: Merz T]]