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==Crystal Structure of BlaC-E166A covalently bound with Mecillinam==
==Crystal Structure of BlaC-E166A covalently bound with Mecillinam==
<StructureSection load='3nc8' size='340' side='right' caption='[[3nc8]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
<StructureSection load='3nc8' size='340' side='right'caption='[[3nc8]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3nc8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NC8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NC8 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3nc8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NC8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NC8 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DH4:2-[(1R)-1-{[(E)-AZEPAN-1-YLMETHYLIDENE]AMINO}-2-OXOETHYL]-5,5-DIMETHYL-1,3-THIAZOLIDINE-4-CARBOXYLIC+ACID'>DH4</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">blaA, blaC, MT2128, MTCY49.07c, Rv2068c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DH4:2-[(1R)-1-{[(E)-AZEPAN-1-YLMETHYLIDENE]AMINO}-2-OXOETHYL]-5,5-DIMETHYL-1,3-THIAZOLIDINE-4-CARBOXYLIC+ACID'>DH4</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nc8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nc8 OCA], [https://pdbe.org/3nc8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nc8 RCSB], [https://www.ebi.ac.uk/pdbsum/3nc8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nc8 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nc8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nc8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3nc8 RCSB], [http://www.ebi.ac.uk/pdbsum/3nc8 PDBsum]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/BLAC_MYCTU BLAC_MYCTU]


==See Also==
==See Also==
*[[Beta-lactamase|Beta-lactamase]]
*[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Beta-lactamase]]
[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Blanchard, J S]]
[[Category: Blanchard JS]]
[[Category: Tremblay, L W]]
[[Category: Tremblay LW]]
[[Category: Beta-lactam covalent adduct]]
[[Category: Hydrolase-antibiotic complex]]
[[Category: Penicillin binding protein]]

Latest revision as of 12:12, 6 September 2023

Crystal Structure of BlaC-E166A covalently bound with MecillinamCrystal Structure of BlaC-E166A covalently bound with Mecillinam

Structural highlights

3nc8 is a 1 chain structure with sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.5Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

BLAC_MYCTU

See Also

3nc8, resolution 1.50Å

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