3n3k: Difference between revisions

<StructureSection load='3n3k' size='340' side='right'caption='[[3n3k]], [[Resolution|resolution]] 2.60&Aring;' scene=''>

<table><tr><td colspan='2'>[[3n3k]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N3K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3N3K FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3n3k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n3k OCA], [https://pdbe.org/3n3k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3n3k RCSB], [https://www.ebi.ac.uk/pdbsum/3n3k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3n3k ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/UBP8_HUMAN UBP8_HUMAN] Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controles tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules. Deubiquitinates BIRC6/bruce and KIF23/MKLP1.<ref>PMID:9628861</ref> <ref>PMID:16520378</ref> <ref>PMID:17711858</ref> <ref>PMID:18329369</ref>  

*[[Thioesterase 3D structures|Thioesterase 3D structures]]

*[[3D structures of ubiquitin|3D structures of ubiquitin]]

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Allali-Hassani A]]

[[Category: Arrowsmith CH]]

[[Category: Avvakumov GV]]

[[Category: Bochkarev A]]

[[Category: Bountra C]]

[[Category: Sidhu S]]

[[Category: Walker JR]]

[[Category: Weigelt J]]

[[Category: Xue S]]