3mpp: Difference between revisions

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-{{Seed}}
-[[Image:3mpp.png|left|200px]]
-<!--
+==Botulinum Neurotoxin Type G Receptor Binding Domain==
-The line below this paragraph, containing "STRUCTURE_3mpp", creates the "Structure Box" on the page.
+<StructureSection load='3mpp' size='340' side='right'caption='[[3mpp]], [[Resolution|resolution]] 1.98&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3mpp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MPP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MPP FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.98&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mpp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mpp OCA], [https://pdbe.org/3mpp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mpp RCSB], [https://www.ebi.ac.uk/pdbsum/3mpp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mpp ProSAT]</span></td></tr>
-{{STRUCTURE_3mpp|  PDB=3mpp  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/BXG_CLOBO BXG_CLOBO] Botulinum toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mp/3mpp_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3mpp ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Botulinum neurotoxin (BoNT) binds peripheral neurons at the neuromuscular junction through a dual-receptor mechanism that includes interactions with ganglioside and protein receptors. The receptor identities vary depending on BoNT serotype (A-G). BoNT/B and BoNT/G bind the luminal domains of synaptotagmin I and II, homologous synaptic vesicle proteins. We observe conditions under which BoNT/B binds both Syt isoforms, but BoNT/G binds only SytI. Both serotypes bind ganglioside G(T1b). The BoNT/G receptor-binding domain crystal structure provides a context for examining these binding interactions and a platform for understanding the physiological relevance of different Syt receptor isoforms in vivo.
-===Botulinum Neurotoxin Type G Receptor Binding Domain===
+Structural Analysis of Botulinum Neurotoxin Type G Receptor Binding .,Schmitt J, Karalewitz A, Benefield DA, Mushrush DJ, Pruitt RN, Spiller BW, Barbieri JT, Lacy DB Biochemistry. 2010 Jun 4. PMID:20507178<ref>PMID:20507178</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 3mpp" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_20507178}}, adds the Publication Abstract to the page
+*[[Botulinum neurotoxin 3D structures|Botulinum neurotoxin 3D structures]]
-(as it appears on PubMed at http://www.pubmed.gov), where 20507178 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_20507178}}
+__TOC__
+</StructureSection>
-==About this Structure==
-MPP is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MPP OCA].
-==Reference==
-<ref group="xtra">PMID:20507178</ref><references group="xtra"/>
-[[Category: Bontoxilysin]]
 [[Category: Clostridium botulinum]]
-[[Category: Lacy, D B.]]
+[[Category: Large Structures]]
-[[Category: Schmitt, J M.]]
+[[Category: Lacy DB]]
-[[Category: Beta barrel beta trefoil]]
+[[Category: Schmitt JM]]
-[[Category: Toxin]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul  7 08:00:13 2010''