3mlm: Difference between revisions

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<StructureSection load='3mlm' size='340' side='right'caption='[[3mlm]], [[Resolution|resolution]] 2.21&Aring;' scene=''>
<StructureSection load='3mlm' size='340' side='right'caption='[[3mlm]], [[Resolution|resolution]] 2.21&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3mlm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bothrops_neuwiedi_pauloensis Bothrops neuwiedi pauloensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MLM OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3MLM FirstGlance]. <br>
<table><tr><td colspan='2'>[[3mlm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bothrops_pauloensis Bothrops pauloensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MLM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MLM FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.21&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3mlm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mlm OCA], [http://pdbe.org/3mlm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3mlm RCSB], [http://www.ebi.ac.uk/pdbsum/3mlm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3mlm ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mlm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mlm OCA], [https://pdbe.org/3mlm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mlm RCSB], [https://www.ebi.ac.uk/pdbsum/3mlm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mlm ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PA2H_BOTPA PA2H_BOTPA]] Snake venom phospholipase A2 (PLA2) that lacks enzymatic activity. Is myotoxic. Displays bactericidal activity and promotes the blockage of the neuromuscular contraction of the chick biventer cervicis muscle. Also disrupts artificial membranes, and provokes tissue damages characterized by edema, necrosis and inflammation. May act as pro-inflammatory mediators, inducing metalloproteinase and cytokine production from the inflammatory and satellite cells.<ref>PMID:10860537</ref> <ref>PMID:9972319</ref> <ref>PMID:14623331</ref>
[https://www.uniprot.org/uniprot/PA2H_BOTPA PA2H_BOTPA] Snake venom phospholipase A2 (PLA2) that lacks enzymatic activity. Is myotoxic. Displays bactericidal activity and promotes the blockage of the neuromuscular contraction of the chick biventer cervicis muscle. Also disrupts artificial membranes, and provokes tissue damages characterized by edema, necrosis and inflammation. May act as pro-inflammatory mediators, inducing metalloproteinase and cytokine production from the inflammatory and satellite cells.<ref>PMID:10860537</ref> <ref>PMID:9972319</ref> <ref>PMID:14623331</ref>  
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== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bothrops neuwiedi pauloensis]]
[[Category: Bothrops pauloensis]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Cavada, B S]]
[[Category: Cavada BS]]
[[Category: Delatorre, P]]
[[Category: Delatorre P]]
[[Category: Gadelha, C A.A]]
[[Category: Gadelha CAA]]
[[Category: Rocha, B A.M]]
[[Category: Rocha BAM]]
[[Category: Toyama, D]]
[[Category: Toyama D]]
[[Category: Toyama, M H]]
[[Category: Toyama MH]]
[[Category: Hydrolase]]
[[Category: Myotoxin]]
[[Category: Phospholipase-like protein]]

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