3mi8: Difference between revisions

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-[[Image:3mi8.jpg|left|200px]]
-<!--
+==The structure of TL1A-DCR3 COMPLEX==
-The line below this paragraph, containing "STRUCTURE_3mi8", creates the "Structure Box" on the page.
+<StructureSection load='3mi8' size='340' side='right'caption='[[3mi8]], [[Resolution|resolution]] 2.95&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3mi8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MI8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MI8 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.951&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mi8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mi8 OCA], [https://pdbe.org/3mi8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mi8 RCSB], [https://www.ebi.ac.uk/pdbsum/3mi8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mi8 ProSAT]</span></td></tr>
-{{STRUCTURE_3mi8|  PDB=3mi8  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/TNF15_HUMAN TNF15_HUMAN] Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis.<ref>PMID:9872942</ref> <ref>PMID:11923219</ref> <ref>PMID:11911831</ref> <ref>PMID:10597252</ref>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Decoy Receptor 3 (DcR3), a secreted member of the Tumor Necrosis Factor (TNF) receptor superfamily, neutralizes three different TNF ligands: FasL, LIGHT, and TL1A. Each of these ligands engages unique signaling receptors which direct distinct and critical immune responses. We report the crystal structures of the unliganded DcR3 ectodomain and its complex with TL1A, as well as complementary mutagenesis and biochemical studies. These analyses demonstrate that DcR3 interacts with invariant backbone and side-chain atoms in the membrane-proximal half of TL1A which supports recognition of its three distinct TNF ligands. Additional features serve as antideterminants that preclude interaction with other members of the TNF superfamily. This mode of interaction is unique among characterized TNF:TNFR family members and provides a mechanistic basis for the broadened specificity required to support the decoy function of DcR3, as well as for the rational manipulation of specificity and affinity of DcR3 and its ligands.
-===The structure of TL1A-DCR3 COMPLEX===
+Decoy Strategies: The Structure of TL1A:DcR3 Complex.,Zhan C, Patskovsky Y, Yan Q, Li Z, Ramagopal U, Cheng H, Brenowitz M, Hui X, Nathenson SG, Almo SC Structure. 2011 Feb 9;19(2):162-71. PMID:21300286<ref>PMID:21300286</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 3mi8" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_21300286}}, adds the Publication Abstract to the page
+*[[Tumor necrosis factor ligand superfamily 3D structures|Tumor necrosis factor ligand superfamily 3D structures]]
-(as it appears on PubMed at http://www.pubmed.gov), where 21300286 is the PubMed ID number.
+*[[Tumor necrosis factor receptor 3D structures|Tumor necrosis factor receptor 3D structures]]
--->
+== References ==
-{{ABSTRACT_PUBMED_21300286}}
+<references/>
+__TOC__
-==About this Structure==
+</StructureSection>
-[[3mi8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermomicrobium_roseum Thermomicrobium roseum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MI8 OCA].
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
-==Reference==
+[[Category: Almo SC]]
-<ref group="xtra">PMID:21300286</ref><references group="xtra"/>
+[[Category: Li Z]]
-[[Category: Thermomicrobium roseum]]
+[[Category: Nathenson SG]]
-[[Category: Almo, S C.]]
+[[Category: Patskovsky Y]]
-[[Category: Li, Z.]]
+[[Category: Ramagopal UA]]
-[[Category: Nathenson, S G.]]
+[[Category: Yan Q]]
-[[Category: Patskovsky, Y.]]
+[[Category: Zhan C]]
-[[Category: Ramagopal, U A.]]
-[[Category: Yan, Q.]]
-[[Category: Zhan, C.]]