3m7f: Difference between revisions

<StructureSection load='3m7f' size='340' side='right'caption='[[3m7f]], [[Resolution|resolution]] 2.00&Aring;' scene=''>

<table><tr><td colspan='2'>[[3m7f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M7F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3M7F FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3m7f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m7f OCA], [https://pdbe.org/3m7f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3m7f RCSB], [https://www.ebi.ac.uk/pdbsum/3m7f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3m7f ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/GRB10_MOUSE GRB10_MOUSE] Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. A similar role in the mediation of ubiquitination has also been suggested with INSR. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2.<ref>PMID:12697834</ref> <ref>PMID:12829789</ref> <ref>PMID:15664450</ref> <ref>PMID:17376403</ref> <ref>PMID:18286479</ref>  

*[[Growth factor receptor-bound proteins 3D structures|Growth factor receptor-bound proteins 3D structures]]

*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]]

[[Category: Huang Q]]

[[Category: Szebenyi M]]