3lin: Difference between revisions

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-[[Image:3lin.png|left|200px]]
-<!--
+==crystal structure of HTLV protease complexed with the inhibitor, KNI-10562==
-The line below this paragraph, containing "STRUCTURE_3lin", creates the "Structure Box" on the page.
+<StructureSection load='3lin' size='340' side='right'caption='[[3lin]], [[Resolution|resolution]] 1.96&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3lin]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_T-cell_leukemia_virus_type_I Human T-cell leukemia virus type I]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LIN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LIN FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.96&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=E13:N-[(2S,3S)-4-{(4R)-4-[(2,2-DIMETHYLPROPYL)CARBAMOYL]-5,5-DIMETHYL-1,3-THIAZOLIDIN-3-YL}-3-HYDROXY-4-OXO-1-PHENYLBUTAN-2-YL]-N~2~-{(2S)-2-[(METHOXYCARBONYL)AMINO]-2-PHENYLACETYL}-3-METHYL-L-VALINAMIDE'>E13</scene></td></tr>
-{{STRUCTURE_3lin|  PDB=3lin  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lin FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lin OCA], [https://pdbe.org/3lin PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lin RCSB], [https://www.ebi.ac.uk/pdbsum/3lin PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lin ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q82134_9DELA Q82134_9DELA]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/li/3lin_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3lin ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Human T-cell leukemia virus type 1 (HTLV-1) is a retrovirus associated with several serious diseases, such as adult T-cell leukemia and tropical spastic paraparesis/myelopathy. For a number of years, the protease (PR) encoded by HTLV-1 has been a target for designing antiviral drugs, but that effort was hampered by limited available structural information. We report a high-resolution crystal structure of HTLV-1 PR complexed with a statine-containing inhibitor, a significant improvement over the previously available moderate-resolution structure. We also report crystal structures of the complexes of HTLV-1 PR with five different inhibitors that are more compact and more potent. A detailed study of structure-activity relationships was performed to interpret in detail the influence of the polar and hydrophobic interactions between the inhibitors and the protease.
-===crystal structure of HTLV protease complexed with the inhibitor, KNI-10562===
+Crystal structures of inhibitor complexes of human T-cell leukemia virus (HTLV-1) protease.,Satoh T, Li M, Nguyen JT, Kiso Y, Gustchina A, Wlodawer A J Mol Biol. 2010 Aug 27;401(4):626-41. Epub 2010 Jun 30. PMID:20600105<ref>PMID:20600105</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 3lin" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_20600105}}, adds the Publication Abstract to the page
+*[[Virus protease 3D structures|Virus protease 3D structures]]
-(as it appears on PubMed at http://www.pubmed.gov), where 20600105 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_20600105}}
+__TOC__
+</StructureSection>
-==About this Structure==
+[[Category: Human T-cell leukemia virus type I]]
-[[3lin]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_t-lymphotropic_virus_1 Human t-lymphotropic virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LIN OCA].
+[[Category: Large Structures]]
+[[Category: Gustchina A]]
-==Reference==
+[[Category: Kiso Y]]
-<ref group="xtra">PMID:20600105</ref><references group="xtra"/>
+[[Category: Li M]]
-[[Category: Human t-lymphotropic virus 1]]
+[[Category: Nguyen J]]
-[[Category: Gustchina, A.]]
+[[Category: Satoh T]]
-[[Category: Kiso, Y.]]
+[[Category: Wlodawer A]]
-[[Category: Li, M.]]
-[[Category: Nguyen, J.]]
-[[Category: Satoh, T.]]
-[[Category: Wlodawer, A.]]