3kv6: Difference between revisions

<StructureSection load='3kv6' size='340' side='right'caption='[[3kv6]], [[Resolution|resolution]] 2.89&Aring;' scene=''>

<table><tr><td colspan='2'>[[3kv6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KV6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KV6 FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.89&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AKG:2-OXOGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=OXY:OXYGEN+MOLECULE'>OXY</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kv6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kv6 OCA], [https://pdbe.org/3kv6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kv6 RCSB], [https://www.ebi.ac.uk/pdbsum/3kv6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kv6 ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/KDM7A_HUMAN KDM7A_HUMAN] Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 in absence of H3K4me3. Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate.<ref>PMID:20023638</ref> <ref>PMID:20194436</ref> <ref>PMID:20622853</ref>  

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Cheng X]]

[[Category: Horton JR]]

[[Category: Qi HH]]

[[Category: Shi Y]]

[[Category: Upadhyay AK]]

[[Category: Zhang X]]