3ki7: Difference between revisions

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-'''Unreleased structure'''
-The entry 3ki7 is ON HOLD  until Oct 25 2011
+==Catalytic fragment of Cholix toxin from Vibrio Cholerae in complex with inhibitor GP-I==
+<StructureSection load='3ki7' size='340' side='right'caption='[[3ki7]], [[Resolution|resolution]] 1.32&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3ki7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KI7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KI7 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.32&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=G9I:2-{2-[4-(PYRROLIDIN-1-YLMETHYL)PHENYL]ETHYL}-5,6-DIHYDROIMIDAZO[4,5,1-JK][1,4]BENZODIAZEPIN-7(4H)-ONE'>G9I</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ki7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ki7 OCA], [https://pdbe.org/3ki7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ki7 RCSB], [https://www.ebi.ac.uk/pdbsum/3ki7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ki7 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/CHXA_VIBCL CHXA_VIBCL] An NAD-dependent ADP-ribosyltransferase (ADPRT), it catalyzes the transfer of the ADP-ribosyl moiety of oxidized NAD onto eukaryotic elongation factor 2 (eEF-2) thus arresting protein synthesis. It probably uses the eukaryotic prolow-density lipoprotein receptor-related protein 1 (LRP1) to enter mouse cells, although there seems to be at least one other receptor as well. Is active against mouse fibroblasts, Chinese hamster ovary eEF-2, brine shrimp (Artemia spp. nauplii) and upon expression in S.cerevisiae.<ref>PMID:18276581</ref> <ref>PMID:19793133</ref>
-Authors: Jorgensen, R., Edwards, P.R., Merrill, A.R.
+==See Also==
+*[[Exotoxin 3D structures|Exotoxin 3D structures]]
-Description: Catalytic fragment of Cholix toxin from Vibrio Cholerae in complex with inhibitor GP-I
+== References ==
+<references/>
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 13 10:26:50 2010''
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Vibrio cholerae]]
+[[Category: Edwards PR]]
+[[Category: Jorgensen R]]
+[[Category: Merrill AR]]