3kci: Difference between revisions

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-{{Seed}}
-[[Image:3kci.jpg|left|200px]]
-<!--
+==The third RLD domain of HERC2==
-The line below this paragraph, containing "STRUCTURE_3kci", creates the "Structure Box" on the page.
+<StructureSection load='3kci' size='340' side='right'caption='[[3kci]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3kci]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KCI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KCI FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kci FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kci OCA], [https://pdbe.org/3kci PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kci RCSB], [https://www.ebi.ac.uk/pdbsum/3kci PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kci ProSAT]</span></td></tr>
-{{STRUCTURE_3kci|  PDB=3kci  |  SCENE=  }}
+</table>
+== Function ==
-===The third RLD domain of HERC2===
+[https://www.uniprot.org/uniprot/HERC2_HUMAN HERC2_HUMAN] E3 ubiquitin-protein ligase that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity.<ref>PMID:20023648</ref> <ref>PMID:20304803</ref> <ref>PMID:22508508</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
-==About this Structure==
+Check<jmol>
-KCI is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KCI OCA].
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kc/3kci_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3kci ConSurf].
+<div style="clear:both"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Arrowsmith, C H.]]
+[[Category: Large Structures]]
-[[Category: Bochkarev, A.]]
+[[Category: Arrowsmith CH]]
-[[Category: Bountra, C.]]
+[[Category: Bochkarev A]]
-[[Category: Dhe-Paganon, S.]]
+[[Category: Bountra C]]
-[[Category: Edwards, A M.]]
+[[Category: Dhe-Paganon S]]
-[[Category: Qiu, L.]]
+[[Category: Edwards AM]]
-[[Category: Vesterberg, A.]]
+[[Category: Qiu L]]
-[[Category: Walker, J R.]]
+[[Category: Vesterberg A]]
-[[Category: Weigelt, J.]]
+[[Category: Walker JR]]
-[[Category: Coiled coil]]
+[[Category: Weigelt J]]
-[[Category: Ligase]]
-[[Category: Metal-binding]]
-[[Category: Phosphoprotein]]
-[[Category: Rcc1]]
-[[Category: Sgc]]
-[[Category: Structural genomics consortium]]
-[[Category: Ubl conjugation pathway]]
-[[Category: Wd repeat]]
-[[Category: Wd40]]
-[[Category: Zinc]]
-[[Category: Zinc-finger]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov  4 11:05:45 2009''