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==Crystal Structure of Spin Labeled T4 Lysozyme Mutant K65V1/R76V1== | |||
<StructureSection load='3k2r' size='340' side='right'caption='[[3k2r]], [[Resolution|resolution]] 1.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3k2r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K2R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3K2R FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HEZ:HEXANE-1,6-DIOL'>HEZ</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=V1A:S-(1-OXYL-2,2,5,5-TETRAMETHYL-2,5-DIHYDRO-1H-IMIDAZOL-4-YL)+METHANESULFONOTHIOATE'>V1A</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3k2r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k2r OCA], [https://pdbe.org/3k2r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3k2r RCSB], [https://www.ebi.ac.uk/pdbsum/3k2r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3k2r ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/ENLYS_BPT4 ENLYS_BPT4] Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.<ref>PMID:22389108</ref> | |||
==See Also== | |||
*[[Lysozyme 3D structures|Lysozyme 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Escherichia virus T4]] | |||
[[Category: Large Structures]] | |||
[[Category: Cascio D]] | |||
[[Category: Hubbell WL]] | |||
[[Category: Khramtsov VV]] | |||
[[Category: Toledo Warshaviak D]] | |||
Latest revision as of 11:08, 6 September 2023
Crystal Structure of Spin Labeled T4 Lysozyme Mutant K65V1/R76V1Crystal Structure of Spin Labeled T4 Lysozyme Mutant K65V1/R76V1
Structural highlights
FunctionENLYS_BPT4 Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.[1] See AlsoReferences
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