3jtk: Difference between revisions
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==Crystal Structure of human type-I N-myristoyltransferase with bound myristoyl-CoA and inhibitor DDD90055== | |||
<StructureSection load='3jtk' size='340' side='right'caption='[[3jtk]], [[Resolution|resolution]] 1.61Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3jtk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JTK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JTK FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.61Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene>, <scene name='pdbligand=X55:(2R)-3-BENZYL-2-(2-BROMO-4-HYDROXY-5-METHOXYPHENYL)-1,3-THIAZOLIDIN-4-ONE'>X55</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jtk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jtk OCA], [https://pdbe.org/3jtk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jtk RCSB], [https://www.ebi.ac.uk/pdbsum/3jtk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jtk ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/NMT1_HUMAN NMT1_HUMAN] Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins. | |||
== Evolutionary Conservation == | |||
== | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | |||
[[ | <jmolCheckbox> | ||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jt/3jtk_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3jtk ConSurf]. | |||
<div style="clear:both"></div> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Arrowsmith | [[Category: Large Structures]] | ||
[[Category: Bochkarev | [[Category: Arrowsmith CH]] | ||
[[Category: Bountra | [[Category: Bochkarev A]] | ||
[[Category: Brand | [[Category: Bountra C]] | ||
[[Category: Cossar | [[Category: Brand SY]] | ||
[[Category: Edwards | [[Category: Cossar D]] | ||
[[Category: Ferguson | [[Category: Edwards AM]] | ||
[[Category: Frearson | [[Category: Ferguson MAJ]] | ||
[[Category: Hui | [[Category: Frearson JA]] | ||
[[Category: Hutchinson | [[Category: Hui R]] | ||
[[Category: Kania | [[Category: Hutchinson A]] | ||
[[Category: Kozieradzki | [[Category: Kania A]] | ||
[[Category: Lin | [[Category: Kozieradzki I]] | ||
[[Category: Qiu | [[Category: Lin Y-H]] | ||
[[Category: Ravichandran | [[Category: Qiu W]] | ||
[[Category: Robinson | [[Category: Ravichandran M]] | ||
[[Category: Robinson DA]] | |||
[[Category: Schapira | [[Category: Schapira M]] | ||
[[Category: Weigelt | [[Category: Weigelt J]] | ||
[[Category: Wernimont | [[Category: Wernimont A]] | ||
[[Category: Wyatt | [[Category: Wyatt PG]] | ||
Latest revision as of 11:03, 6 September 2023
Crystal Structure of human type-I N-myristoyltransferase with bound myristoyl-CoA and inhibitor DDD90055Crystal Structure of human type-I N-myristoyltransferase with bound myristoyl-CoA and inhibitor DDD90055
Structural highlights
FunctionNMT1_HUMAN Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. |
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