3jpr: Difference between revisions

<StructureSection load='3jpr' size='340' side='right'caption='[[3jpr]], [[Resolution|resolution]] 2.10&Aring;' scene=''>

<table><tr><td colspan='2'>[[3jpr]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JPR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JPR FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DOC:2,3-DIDEOXYCYTIDINE-5-MONOPHOSPHATE'>DOC</scene>, <scene name='pdbligand=G2M:2-DEOXY-5-O-[(S)-HYDROXY{[(S)-HYDROXY(1-METHYL-1-PHOSPHONOETHYL)PHOSPHORYL]OXY}PHOSPHORYL]GUANOSINE'>G2M</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jpr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jpr OCA], [https://pdbe.org/3jpr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jpr RCSB], [https://www.ebi.ac.uk/pdbsum/3jpr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jpr ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/DPOLB_HUMAN DPOLB_HUMAN] Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.<ref>PMID:9207062</ref> <ref>PMID:9572863</ref> <ref>PMID:11805079</ref> <ref>PMID:21362556</ref>  

*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Batra VK]]

[[Category: Beard WA]]

[[Category: Goodman MF]]

[[Category: Kashmerov B]]

[[Category: McKenna CE]]

[[Category: Upton J]]

[[Category: Wilson SH]]