3ihp: Difference between revisions

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-{{Seed}}
-[[Image:3ihp.jpg|left|200px]]
-<!--
+==Covalent Ubiquitin-Usp5 Complex==
-The line below this paragraph, containing "STRUCTURE_3ihp", creates the "Structure Box" on the page.
+<StructureSection load='3ihp' size='340' side='right'caption='[[3ihp]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3ihp]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IHP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IHP FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NEH:ETHANAMINE'>NEH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-{{STRUCTURE_3ihp|  PDB=3ihp  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ihp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ihp OCA], [https://pdbe.org/3ihp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ihp RCSB], [https://www.ebi.ac.uk/pdbsum/3ihp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ihp ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/UBP5_HUMAN UBP5_HUMAN] Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys-63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition.<ref>PMID:19098288</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ih/3ihp_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ihp ConSurf].
+<div style="clear:both"></div>
-===Covalent Ubiquitin-Usp5 Complex===
+==See Also==
+*[[Thioesterase 3D structures|Thioesterase 3D structures]]
+*[[3D structures of ubiquitin|3D structures of ubiquitin]]
-==About this Structure==
+== References ==
-IHP is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IHP OCA].
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Ubiquitin thiolesterase]]
+[[Category: Large Structures]]
-[[Category: Arrowsmith, C H.]]
+[[Category: Arrowsmith CH]]
-[[Category: Avvakumov, G V.]]
+[[Category: Avvakumov GV]]
-[[Category: Bochkarev, A.]]
+[[Category: Bochkarev A]]
-[[Category: Bountra, C.]]
+[[Category: Bountra C]]
-[[Category: Butler-Cole, C.]]
+[[Category: Butler-Cole C]]
-[[Category: Dhe-Paganon, S.]]
+[[Category: Dhe-Paganon S]]
-[[Category: Edwards, A M.]]
+[[Category: Edwards AM]]
-[[Category: SGC, Structural Genomics Consortium.]]
+[[Category: Walker JR]]
-[[Category: Walker, J R.]]
+[[Category: Weigelt J]]
-[[Category: Weigelt, J.]]
+[[Category: Xue S]]
-[[Category: Xue, S.]]
-[[Category: Acetylation]]
-[[Category: Alternative splicing]]
-[[Category: Cytoplasm]]
-[[Category: Hydrolase]]
-[[Category: Isopeptide bond]]
-[[Category: Metal-binding]]
-[[Category: Nucleus]]
-[[Category: Phosphoprotein]]
-[[Category: Protease]]
-[[Category: Sgc]]
-[[Category: Structural genomic]]
-[[Category: Structural genomics consortium]]
-[[Category: Thiol protease]]
-[[Category: Ubl conjugation]]
-[[Category: Ubl conjugation pathway]]
-[[Category: Zinc]]
-[[Category: Zinc-finger]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 30 14:45:01 2009''