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==Crystal structure of N-terminal domain of Plasmodium falciparum Hsp90 (PF14_0417) in complex with AMPPN==
==Crystal structure of N-terminal domain of Plasmodium falciparum Hsp90 (PF14_0417) in complex with AMPPN==
<StructureSection load='3ied' size='340' side='right' caption='[[3ied]], [[Resolution|resolution]] 2.01&Aring;' scene=''>
<StructureSection load='3ied' size='340' side='right'caption='[[3ied]], [[Resolution|resolution]] 2.01&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3ied]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plaf7 Plaf7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IED OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IED FirstGlance]. <br>
<table><tr><td colspan='2'>[[3ied]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IED OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IED FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AN2:AMP+PHOSPHORAMIDATE'>AN2</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.01&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1y6z|1y6z]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AN2:AMP+PHOSPHORAMIDATE'>AN2</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PF14_0417 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36329 PLAF7])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ied FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ied OCA], [https://pdbe.org/3ied PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ied RCSB], [https://www.ebi.ac.uk/pdbsum/3ied PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ied ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ied FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ied OCA], [http://pdbe.org/3ied PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ied RCSB], [http://www.ebi.ac.uk/pdbsum/3ied PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ied ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q8IL32_PLAF7 Q8IL32_PLAF7]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ie/3ied_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ie/3ied_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ied ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ied ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
==See Also==
*[[Heat Shock Protein structures|Heat Shock Protein structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Plaf7]]
[[Category: Large Structures]]
[[Category: Amaya, M F]]
[[Category: Plasmodium falciparum 3D7]]
[[Category: Arrowsmith, C H]]
[[Category: Amaya MF]]
[[Category: Artz, J D]]
[[Category: Arrowsmith CH]]
[[Category: Botchkarev, A]]
[[Category: Artz JD]]
[[Category: Bountra, C]]
[[Category: Botchkarev A]]
[[Category: Edwards, A M]]
[[Category: Bountra C]]
[[Category: Hills, T]]
[[Category: Edwards AM]]
[[Category: Hui, R]]
[[Category: Hills T]]
[[Category: Hutchinson, A]]
[[Category: Hui R]]
[[Category: Kozieradzki, I]]
[[Category: Hutchinson A]]
[[Category: Lew, J]]
[[Category: Kozieradzki I]]
[[Category: Pizarro, J C]]
[[Category: Lew J]]
[[Category: Plotnikova, O]]
[[Category: Pizarro JC]]
[[Category: Structural genomic]]
[[Category: Plotnikova O]]
[[Category: Vedadi, M]]
[[Category: Vedadi M]]
[[Category: Weigelt, J]]
[[Category: Weigelt J]]
[[Category: Wernimont, A K]]
[[Category: Wernimont AK]]
[[Category: Chaperone]]
[[Category: Hsp90]]
[[Category: Plasmodium]]
[[Category: Sgc]]
[[Category: Stress response]]

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