3i2e: Difference between revisions
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==Crystal structure of human dimethylarginine dymethylaminohydrolase-1 (DDAH-1)== | ==Crystal structure of human dimethylarginine dymethylaminohydrolase-1 (DDAH-1)== | ||
<StructureSection load='3i2e' size='340' side='right' caption='[[3i2e]], [[Resolution|resolution]] 2.03Å' scene=''> | <StructureSection load='3i2e' size='340' side='right'caption='[[3i2e]], [[Resolution|resolution]] 2.03Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3i2e]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[3i2e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I2E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3I2E FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.03Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3i2e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i2e OCA], [https://pdbe.org/3i2e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3i2e RCSB], [https://www.ebi.ac.uk/pdbsum/3i2e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3i2e ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/DDAH1_HUMAN DDAH1_HUMAN] Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i2/3i2e_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i2/3i2e_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Fast | [[Category: Fast W]] | ||
[[Category: Hu | [[Category: Hu S]] | ||
[[Category: Monzingo | [[Category: Monzingo AF]] | ||
[[Category: Robertus | [[Category: Robertus JD]] | ||
[[Category: Schaller | [[Category: Schaller TH]] | ||
[[Category: Wang | [[Category: Wang Y]] | ||