3hsm: Difference between revisions
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<StructureSection load='3hsm' size='340' side='right'caption='[[3hsm]], [[Resolution|resolution]] 2.50Å' scene=''> | <StructureSection load='3hsm' size='340' side='right'caption='[[3hsm]], [[Resolution|resolution]] 2.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3hsm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[3hsm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HSM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HSM FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hsm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hsm OCA], [https://pdbe.org/3hsm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hsm RCSB], [https://www.ebi.ac.uk/pdbsum/3hsm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hsm ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hsm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hsm OCA], [https://pdbe.org/3hsm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hsm RCSB], [https://www.ebi.ac.uk/pdbsum/3hsm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hsm ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/RYR1_RABIT RYR1_RABIT] Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm. Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By similarity).<ref>PMID:10388749</ref> <ref>PMID:22036948</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Amador | [[Category: Oryctolagus cuniculus]] | ||
[[Category: Ikura | [[Category: Amador FJ]] | ||
[[Category: Ishiyama | [[Category: Ikura M]] | ||
[[Category: Liu | [[Category: Ishiyama N]] | ||
[[Category: MacLennan | [[Category: Liu S]] | ||
[[Category: Plevin | [[Category: MacLennan DH]] | ||
[[Category: Wilson | [[Category: Plevin MJ]] | ||
[[Category: Wilson A]] | |||