3hh3: Difference between revisions

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[[Image:3hh3.jpg|left|200px]]


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==New azaborine compounds bind to the T4 lysozyme L99A cavity - 1,2-dihydro-1,2-azaborine==
The line below this paragraph, containing "STRUCTURE_3hh3", creates the "Structure Box" on the page.
<StructureSection load='3hh3' size='340' side='right'caption='[[3hh3]], [[Resolution|resolution]] 1.25&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3hh3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HH3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HH3 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.25&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B20:1,2-DIHYDRO-1,2-AZABORININE'>B20</scene>, <scene name='pdbligand=HED:2-HYDROXYETHYL+DISULFIDE'>HED</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
{{STRUCTURE_3hh3| PDB=3hh3 |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hh3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hh3 OCA], [https://pdbe.org/3hh3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hh3 RCSB], [https://www.ebi.ac.uk/pdbsum/3hh3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hh3 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ENLYS_BPT4 ENLYS_BPT4] Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.<ref>PMID:22389108</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hh/3hh3_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hh3 ConSurf].
<div style="clear:both"></div>


===New azaborine compounds bind to the T4 lysozyme L99A cavity - 1,2-dihydro-1,2-azaborine===
==See Also==
 
*[[Lysozyme 3D structures|Lysozyme 3D structures]]
 
== References ==
==About this Structure==
<references/>
3HH3 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_t4 Enterobacteria phage t4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HH3 OCA].
__TOC__
 
</StructureSection>
==Reference==
[[Category: Escherichia virus T4]]
<ref group="xtra">PMID:19688806</ref><references group="xtra"/>
[[Category: Large Structures]]
[[Category: Enterobacteria phage t4]]
[[Category: Liu L]]
[[Category: Lysozyme]]
[[Category: Matthews BW]]
[[Category: Liu, L.]]
[[Category: Matthews, B W.]]
[[Category: Antimicrobial]]
[[Category: Azaborine]]
[[Category: Bacteriolytic enzyme]]
[[Category: Glycosidase]]
[[Category: Hydrolase]]
[[Category: Hydrophobic cavity]]
[[Category: Ligand binding]]
[[Category: T4 lysozyme]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 14 10:26:36 2009''

Latest revision as of 10:21, 6 September 2023

New azaborine compounds bind to the T4 lysozyme L99A cavity - 1,2-dihydro-1,2-azaborineNew azaborine compounds bind to the T4 lysozyme L99A cavity - 1,2-dihydro-1,2-azaborine

Structural highlights

3hh3 is a 1 chain structure with sequence from Escherichia virus T4. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.25Å
Ligands:, , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ENLYS_BPT4 Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Moussa SH, Kuznetsov V, Tran TA, Sacchettini JC, Young R. Protein determinants of phage T4 lysis inhibition. Protein Sci. 2012 Apr;21(4):571-82. doi: 10.1002/pro.2042. Epub 2012 Mar 2. PMID:22389108 doi:http://dx.doi.org/10.1002/pro.2042

3hh3, resolution 1.25Å

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