3gdi: Difference between revisions

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==Mammalian Clock Protein mPER2 - Crystal Structure of a PAS Domain Fragment==
==Mammalian Clock Protein mPER2 - Crystal Structure of a PAS Domain Fragment==
<StructureSection load='3gdi' size='340' side='right' caption='[[3gdi]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='3gdi' size='340' side='right'caption='[[3gdi]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3gdi]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GDI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GDI FirstGlance]. <br>
<table><tr><td colspan='2'>[[3gdi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GDI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GDI FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gdi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gdi OCA], [http://pdbe.org/3gdi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3gdi RCSB], [http://www.ebi.ac.uk/pdbsum/3gdi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3gdi ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gdi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gdi OCA], [https://pdbe.org/3gdi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gdi RCSB], [https://www.ebi.ac.uk/pdbsum/3gdi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gdi ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PER2_MOUSE PER2_MOUSE]] Component of the circadian clock mechanism which is essential for generating circadian rhythms. Negative element in the circadian transcriptional loop. Influences clock function by interacting with other circadian regulatory proteins and transporting them to the nucleus. Negatively regulates CLOCK|NPAS2-BMAL1|BMAL2-induced transactivation.<ref>PMID:10428031</ref> <ref>PMID:17310242</ref>
[https://www.uniprot.org/uniprot/PER2_MOUSE PER2_MOUSE] Component of the circadian clock mechanism which is essential for generating circadian rhythms. Negative element in the circadian transcriptional loop. Influences clock function by interacting with other circadian regulatory proteins and transporting them to the nucleus. Negatively regulates CLOCK|NPAS2-BMAL1|BMAL2-induced transactivation.<ref>PMID:10428031</ref> <ref>PMID:17310242</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gd/3gdi_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gd/3gdi_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
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</div>
</div>
<div class="pdbe-citations 3gdi" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 3gdi" style="background-color:#fffaf0;"></div>
==See Also==
*[[Period circadian protein|Period circadian protein]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Hennig, S]]
[[Category: Large Structures]]
[[Category: Wolf, E]]
[[Category: Mus musculus]]
[[Category: Biological rhythm]]
[[Category: Hennig S]]
[[Category: Nucleus]]
[[Category: Wolf E]]
[[Category: Phosphoprotein]]
[[Category: Tandem pas domain]]
[[Category: Transcription]]
[[Category: Transcription regulation]]

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