3es9: Difference between revisions

No edit summary
No edit summary
 
(One intermediate revision by the same user not shown)
Line 1: Line 1:


==NADPH-Cytochrome P450 Reductase in an Open Conformation==
==NADPH-Cytochrome P450 Reductase in an Open Conformation==
<StructureSection load='3es9' size='340' side='right' caption='[[3es9]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
<StructureSection load='3es9' size='340' side='right'caption='[[3es9]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3es9]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ES9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ES9 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3es9]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ES9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ES9 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CYPOR, Por ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NADPH--hemoprotein_reductase NADPH--hemoprotein reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.6.2.4 1.6.2.4] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3es9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3es9 OCA], [https://pdbe.org/3es9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3es9 RCSB], [https://www.ebi.ac.uk/pdbsum/3es9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3es9 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3es9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3es9 OCA], [http://pdbe.org/3es9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3es9 RCSB], [http://www.ebi.ac.uk/pdbsum/3es9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3es9 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/NCPR_RAT NCPR_RAT]] This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.  
[https://www.uniprot.org/uniprot/NCPR_RAT NCPR_RAT] This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 32: Line 31:


==See Also==
==See Also==
*[[NADPH Cytochrome P450 Oxidoreductase|NADPH Cytochrome P450 Oxidoreductase]]
*[[NADPH-Cytochrome P450 Reductase|NADPH-Cytochrome P450 Reductase]]
*[[NADPH-Cytochrome P450 Reductase|NADPH-Cytochrome P450 Reductase]]
== References ==
== References ==
Line 38: Line 36:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Buffalo rat]]
[[Category: Large Structures]]
[[Category: NADPH--hemoprotein reductase]]
[[Category: Rattus norvegicus]]
[[Category: Hamdane, D]]
[[Category: Hamdane D]]
[[Category: Im, S C]]
[[Category: Im S-C]]
[[Category: Kim, J J]]
[[Category: Kim J-J]]
[[Category: Waskell, L]]
[[Category: Waskell L]]
[[Category: Xia, C]]
[[Category: Xia C]]
[[Category: Zhang, H]]
[[Category: Zhang H]]
[[Category: Acetylation]]
[[Category: Cytochrome p450 reductase]]
[[Category: Endoplasmic reticulum]]
[[Category: Fad]]
[[Category: Flavoprotein]]
[[Category: Fmn]]
[[Category: Membrane]]
[[Category: Nadp]]
[[Category: Open conformation]]
[[Category: Oxidoreductase]]
[[Category: Phosphoprotein]]

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA