3er0: Difference between revisions
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==Crystal structure of the full length eIF5A from Saccharomyces cerevisiae== | |||
<StructureSection load='3er0' size='340' side='right'caption='[[3er0]], [[Resolution|resolution]] 3.35Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3er0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ER0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ER0 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.35Å</td></tr> | |||
== | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3er0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3er0 OCA], [https://pdbe.org/3er0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3er0 RCSB], [https://www.ebi.ac.uk/pdbsum/3er0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3er0 ProSAT]</span></td></tr> | ||
[[3er0]] is a 2 chain structure with sequence from [ | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/IF5A1_YEAST IF5A1_YEAST] mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Essential for polarized growth, a process necessary for G1/S transition. May mediate large range of effects of the polyamine spermidine in the cell.<ref>PMID:10229683</ref> <ref>PMID:16157662</ref> <ref>PMID:16408210</ref> <ref>PMID:16914118</ref> <ref>PMID:19338753</ref> <ref>PMID:19424157</ref> <ref>PMID:641056</ref> <ref>PMID:8307948</ref> <ref>PMID:9582285</ref> | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/er/3er0_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3er0 ConSurf]. | |||
<div style="clear:both"></div> | |||
==See Also== | ==See Also== | ||
*[[Eukaryotic initiation factor|Eukaryotic initiation factor]] | *[[Eukaryotic initiation factor 3D structures|Eukaryotic initiation factor 3D structures]] | ||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Saccharomyces cerevisiae]] | [[Category: Saccharomyces cerevisiae]] | ||
[[Category: Aponi | [[Category: Aponi LH]] | ||
[[Category: Dias | [[Category: Dias CAO]] | ||
[[Category: Guimaraes | [[Category: Guimaraes B]] | ||
[[Category: Sanches | [[Category: Sanches M]] | ||
[[Category: Valentini | [[Category: Valentini SR]] | ||