Polyhedrin: Difference between revisions

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<StructureSection load='4s1k' size='340' side='right' caption='Polyhedrin complex with ATP (PDB code [[4s1k]])' scene=''>
<StructureSection load='4s1k' size='340' side='right' caption='Polyhedrin complex with ATP (PDB code [[4s1k]])' scene='87/873252/Cv/1'>
'''Polyhedrin''' is a viral protein which forms a protective layer around a virus and resists its solubilization and thus ensures its long-term viability<ref>PMID:3525744</ref>.
'''Polyhedrin''' is a viral protein in cytoplasmic polyhedrosis viruses which parasitize insects.  Polyhedrin forms a protective layer around a virus and resists its solubilization and thus ensures its long-term viability<ref>PMID:3525744</ref>.


== Function ==
== Relevance ==
 
== Disease ==


== Relevance ==
Polyhedrins protect viruses which cause disease in silkworm<ref>PMID:17462666</ref>.


== Structural highlights ==
== Structural highlights ==


The biological assembly of ''Uranotaenia sapphirina'' cypovirus Polyhedrin is <scene name='87/873252/Cv/2'>homotrimer</scene> (PDB code [[4s1k]]). <scene name='87/873252/Cv/9'>ATP binding site</scene><ref>PMID:25751308</ref>. Water molecules are shown as red spheres. <scene name='87/873252/Cv/10'>Mg coordination site</scene>.


</StructureSection>
</StructureSection>
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|
*Polyhedrin
**[[3jvb]] – PH – wiseana signata nucleopolyhedrovirus<br />
**[[2wux]], [[2wuy]], [[3jw6]] – PH – autographa californica nucleopolyhedrovirus<br />
**[[5gqk]], [[5yha]], [[5yhb]], [[7xhr]], [[7xws]] – bmcvPH – bombyx mori cypovirus<br />
**[[5a9b]], [[5gqi]], [[5gqj]], [[5gqn]], [[5yr1]], [[5yr9]], [[5yra]], [[5yrb]], [[5yrc]], [[5yrd]], [[6lee]] – bmcvPH (mutant)<br />
**[[5a8s]], [[5a8t]], [[5a9c]] – PH (mutant) – antheraea mylitta cypovirus<br />
**[[5a8u]], [[5a8v]] – PH – orgyia pseudotsugata cypovirus<br />
**[[5g0z]], [[5g3x]] – PH – cydia pomonella granulovirus<br />
**[[8bbt]], [[8bc5]], [[8bck]], [[8bcl]] – PH – tipula oleracea nudivirus<br />
*Polyhedrin complex
**[[4s1k]], [[4s1l]], [[4zqx]] – PH + ATP – uranotaenia sapphirina cypovirus<br />
**[[5a99]] – obcvPH + ATP – operophtera brumata cypovirus<br />
**[[4ots]], [[4otv]], [[4x35]], [[5a9p]], [[5mqw]] – obcvPH + ATP + GTP<br />
**[[5axv]] – bmcvPH (mutant) + CTP<br />
**[[5gql]] – bmcvPH + ATP + CTP<br />
**[[5axu]] – bmcvPH (mutant) + ATP + CTP<br />
**[[2oh5]], [[2oh6]], [[2oh7]], [[5exy]], [[5exz]], [[5gqm]] – bmcvPH + ATP + GTP + CTP<br />
**[[5a96]] – PH + GTP – lymantria dispar cypovirus<br />
**[[5a98]] – PH + ATP – trichoplusia ni cypovirus<br />
**[[5a9a]] – PH + UTP – simullium ubuquitum cypovirus<br />
}}


[[3jvb]] – PH – wiseana signata nucleopolyhedrovirus<br />
[[2wux]], [[2wuy]], [[3jw6]] – PH – autographa californica nucleopolyhedrovirus<br />
[[4s1k]], [[4s1l]], [[4zqx]] – PH + ATP – uranotaenia sapphirina cypovirus<br />
[[5a99]] – obcvPH + ATP – operophtera brumata cypovirus<br />
[[4ots]], [[4otv]], [[4x35]], [[5a9p]], [[5mqw]] – obcvPH + ATP + GTP<br />
[[5gqk]], [[5yha]], [[5yhb]] – bmcvPH – bombyx mori cypovirus<br />
[[5a9b]], [[5gqi]], [[5gqj]], [[5gqn]], [[5yr1]], [[5yr9]], [[5yra]], [[5yrb]], [[5yrc]], [[5yrd]], [[6lee]] – bmcvPH (mutant)<br />
[[5axv]] – bmcvPH (mutant) + CTP<br />
[[5gql]] – bmcvPH + ATP + CTP<br />
[[5axu]] – bmcvPH (mutant) + ATP + CTP<br />
[[2oh5]], [[2oh6]], [[2oh7]], [[5exy]], [[5exz]], [[5gqm]] – bmcvPH + ATP + GTP + CTP<br />
[[5a96]] – PH + GTP – lymantria dispar cypovirus<br />
[[5a8s]], [[5a8t]], [[5a9c]] – PH (mutant) – antheraea mylitta cypovirus<br />
[[5a98]] – PH + ATP – trichoplusia ni cypovirus<br />
[[5a9a]] – PH + UTP – simullium ubuquitum cypovirus<br />
[[5a8u]], [[5a8v]] – PH – orgyia pseudotsugata cypovirus<br />
[[5g3x]] – PH – cydia pomonella granulovirus<br />
== References ==
== References ==
<references/>
<references/>


[[Category:Topic Page]]
[[Category:Topic Page]]

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky