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| *'''Plexin A''' controls axon guidance<ref>PMID:9875845</ref>. | | *'''Plexin A''' controls axon guidance<ref>PMID:9875845</ref>. |
| *'''Plexin B''' regulates Rho GTPase<ref>PMID:12183458</ref>. | | *'''Plexin B''' regulates Rho GTPase<ref>PMID:12183458</ref>. |
| | *'''Plexin C''' is the receptor for GPI-anchored semaphorin Sema7A<ref>PMID:10520995</ref>. |
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| == Structural highlights == | | == Structural highlights == |
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| *<scene name='46/466532/Cv/4'>Plexin C1 interactions with semaphoric SEMA7A</scene>. Water molecules are shown as red spheres. | | *<scene name='46/466532/Cv/4'>Plexin C1 interactions with semaphoric SEMA7A</scene>. Water molecules are shown as red spheres. |
| *<scene name='46/466532/Cv/5'>Ca coordination site</scene>. | | *<scene name='46/466532/Cv/5'>Ca coordination site</scene>. |
| | ==3D structures of plexin== |
| | [[Plexin 3D structures]] |
| </StructureSection> | | </StructureSection> |
| ==3D structures of plexin==
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| {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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| {{#tree:id=OrganizedByTopic|openlevels=0|
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| *Plexin A
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| **[[5l56]], [[5l59]], [[5l5c]] – mPLX-A1 extracellular domain segment 1-10 - mouse<br />
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| **[[5l7n]] – mPLX-A1 extracellular domain segment 7-10<br />
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| **[[3ryt]] - mPLX-A1 intracellular domain + Ras-related C3 botulinum toxin substrate<br />
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| **[[3q3j]] - hPLX-A2 binding domain + Rho-related GTP-binding protein Rho6 – human<br />
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| **[[3al8]], [[3oky]] – mPLX-A2 + semaphorin-6A <br />
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| **[[4gza]] - mPLX-A2 + semaphorin-3A + neuropilin-1<br />
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| **[[3al9]] – mPLX-A2 SEMA+PSI domain<br />
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| **[[3okt]] - mPLX-A2 extracellular domain segment 1-4<br />
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| **[[5l5g]] – mPLX-A2 extracellular domain segment 1-8<br />
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| **[[5l74]] – mPLX-A2 extracellular domain segment 4-5<br />
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| **[[3ig3]] - mPLX-A3 intracellular domain<br />
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| **[[4e74]] - hPLX-A4 Rho GTPase-binding domain<br />
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| **[[5l5k]], [[5l5l]] – mPLX-A4 extracellular domain <br />
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| **[[5l5k]] – mPLX-A4 extracellular domain segment 1-10<br />
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| **[[5l5l]] – mPLX-A4 extracellular domain segment 1-8<br />
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| **[[5l5m]], [[5l5n]] – mPLX-A4 extracellular domain segment 1-7<br />
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| **[[6fkm]], [[6fkn]] - PLX-A + semaphoring – ''Drosophila melanogaster''<br />
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| *Plexin B
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| **[[2r2o]] – hPLX-B1 effector domain
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| **[[2rex]] - hPLX-B1 effector domain + Rho-related GTP-binding protein Rho6
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| **[[2jph]] - hPLX-B1 effector domain – NMR<br />
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| **[[3ol2]] - hPLX-B1 + semaphorin 4D
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| **[[3sua]], [[3su8]] – hPLX-B1 + RAS-related C3 botulinum toxin substrate
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| **[[3hm6]] - hPLX-B1 cytoplasmic domain + peptide<br />
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| **[[5b4w]] - hPLX-B1 residues 20-535 + peptide inhibitor<br />
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| **[[4e71]] - hPLX-B2 effector domain<br />
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| **[[5e6p]] - hPLX-B2 cytoplasmic domain + Rho guanine nucleotide exchange factor 11<br />
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| *Plexin C
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| **[[3kuz]] - hPLX-C1 ubiquitin-like domain
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| **[[3nvn]], [[3nvq]] – hPLX-C1 + semaphorin 7A<br />
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| **[[6vxk]] - hPLX-C1 + semaphorin-like protein – Cryo EM<br />
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| **[[4m8n]] - PLX-C1 intracellular domain + RAP1B – zebra fish<br />
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| *Plexin D
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| **[[3h6n]] - hPLX-D1 ubiquitin-like domain<br />
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| **[[5v6r]] - mPLX-D1 intracellular domain <br />
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| **[[5v6t]] - mPLX-D1 intracellular domain + GIPC1<br />
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| }}
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| == References == | | == References == |
| <references/> | | <references/> |
| [[Category:Topic Page]] | | [[Category:Topic Page]] |