Plexin: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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-<StructureSection load='3nvn' size='350' side='right' caption='Glycosylated human plexin C1 (green) complex with semaphoric SEMA7A (grey) and Ca+2 ion (green) (PDB entry [[3nvn]])' scene=''>
+<StructureSection load='' size='350' side='right' caption='Glycosylated human plexin C1 (magenta) complex with semaphoric SEMA7A (green) and Ca+2 ion (green) (PDB entry [[3nvn]])' scene='46/466532/Cv/1' pspeed='8'>
 '''Plexin''' (PLX) is the receptor for semaphorin<ref>PMID:20877282</ref>.
 *'''Plexin A''' controls axon guidance<ref>PMID:9875845</ref>.
 *'''Plexin B''' regulates Rho GTPase<ref>PMID:12183458</ref>.
-</StructureSection>
+*'''Plexin C''' is the receptor for GPI-anchored semaphorin Sema7A<ref>PMID:10520995</ref>.
-==3D structures of plexin==
-{{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+== Structural highlights ==
-{{#tree:id=OrganizedByTopic|openlevels=0|
-*Plexin A
+*<scene name='46/466532/Cv/4'>Plexin C1 interactions with semaphoric SEMA7A</scene>. Water molecules are shown as red spheres.
+*<scene name='46/466532/Cv/5'>Ca coordination site</scene>.
-**[[3al8]], [[3oky]] – mPLX-A2 + semaphorin-6A – mouse<br />
+==3D structures of plexin==
-**[[4gza]] - mPLX-A2 + semaphorin-3A + neuropilin-1<br />
+[[Plexin 3D structures]]
-**[[3al9]], [[3okt]] – mPLX-A2 extracellular domain<br />
+</StructureSection>
-**[[3ig3]] - mPLX-A3 intracellular domain<br />
-**[[3ryt]] - mPLX-A1 intracellular domain + Ras-related C3 botulinum toxin substrate<br />
-**[[3q3j]] - hPLX-A2  binding domain + Rho-related GTP-binding protein Rho6 – human<br />
-**[[4e74]] - hPLX-A4 Rho GTPase-binding domain
-*Plexin B
-**[[2r2o]] – hPLX-B1 effector domain
-**[[2rex]] - hPLX-B1 effector domain + Rho-related GTP-binding protein Rho6
-**[[2jph]] - hPLX-B1 Rho GTPase-binding domain – NMR<br />
-**[[4e71]] - hPLX-B2 Rho GTPase-binding domain<br />
-**[[3ol2]] - hPLX-B1 + semaphorin 4D
-**[[3sua]], [[3su8]] – hPLX-B1 + RAS-related C3 botulinum toxin substrate
-**[[3hm6]] - hPLX-B1 cytoplasmic domain + peptide
-*Plexin C
-**[[3kuz]] - hPLX-C1 ubiquitin-like domain
-**[[3nvn]], [[3nvq]] – hPLX-C1 + semaphorin 7A
-*Plexin D
-**[[3h6n]] - hPLX-D1 ubiquitin-like domain
-}}
 == References ==
 <references/>
 [[Category:Topic Page]]