Plexin: Difference between revisions

Latest revision as of 11:41, 3 September 2023

Plexin (PLX) is the receptor for semaphorin^[1].

Plexin A controls axon guidance^[2].
Plexin B regulates Rho GTPase^[3].
Plexin C is the receptor for GPI-anchored semaphorin Sema7A^[4].

Structural highlights

. Water molecules are shown as red spheres.
.

3D structures of plexin

Plexin 3D structures

Glycosylated human plexin C1 (magenta) complex with semaphoric SEMA7A (green) and Ca+2 ion (green) (PDB entry 3nvn)

Drag the structure with the mouse to rotate

ReferencesReferences

↑ Janssen BJ, Robinson RA, Perez-Branguli F, Bell CH, Mitchell KJ, Siebold C, Jones EY. Structural basis of semaphorin-plexin signalling. Nature. 2010 Sep 26. PMID:20877282 doi:10.1038/nature09468
↑ Winberg ML, Noordermeer JN, Tamagnone L, Comoglio PM, Spriggs MK, Tessier-Lavigne M, Goodman CS. Plexin A is a neuronal semaphorin receptor that controls axon guidance. Cell. 1998 Dec 23;95(7):903-16. PMID:9875845
↑ Perrot V, Vazquez-Prado J, Gutkind JS. Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF. J Biol Chem. 2002 Nov 8;277(45):43115-20. Epub 2002 Aug 14. PMID:12183458 doi:http://dx.doi.org/10.1074/jbc.M206005200
↑ Tamagnone L, Artigiani S, Chen H, He Z, Ming GI, Song H, Chedotal A, Winberg ML, Goodman CS, Poo M, Tessier-Lavigne M, Comoglio PM. Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates. Cell. 1999 Oct 1;99(1):71-80. PMID:10520995

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Michal Harel, Alexander Berchansky, Joel L. Sussman

[1] Janssen BJ, Robinson RA, Perez-Branguli F, Bell CH, Mitchell KJ, Siebold C, Jones EY. Structural basis of semaphorin-plexin signalling. Nature. 2010 Sep 26. PMID:20877282 doi:10.1038/nature09468

[2] Winberg ML, Noordermeer JN, Tamagnone L, Comoglio PM, Spriggs MK, Tessier-Lavigne M, Goodman CS. Plexin A is a neuronal semaphorin receptor that controls axon guidance. Cell. 1998 Dec 23;95(7):903-16. PMID:9875845

[3] Perrot V, Vazquez-Prado J, Gutkind JS. Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF. J Biol Chem. 2002 Nov 8;277(45):43115-20. Epub 2002 Aug 14. PMID:12183458 doi:http://dx.doi.org/10.1074/jbc.M206005200

[4] Tamagnone L, Artigiani S, Chen H, He Z, Ming GI, Song H, Chedotal A, Winberg ML, Goodman CS, Poo M, Tessier-Lavigne M, Comoglio PM. Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates. Cell. 1999 Oct 1;99(1):71-80. PMID:10520995

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@@ Line 1: / Line 1: @@
-{{STRUCTURE_3ig3| PDB=3ig3  | SIZE=400| SCENE= |right|CAPTION=Mouse plexin-A3 intracellular domain complex with glycerol, [[3ig3]] }}
+<StructureSection load='' size='350' side='right' caption='Glycosylated human plexin C1 (magenta) complex with semaphoric SEMA7A (green) and Ca+2 ion (green) (PDB entry [[3nvn]])' scene='46/466532/Cv/1' pspeed='8'>
 '''Plexin''' (PLX) is the receptor for semaphorin<ref>PMID:20877282</ref>.
-==3D structures of plexin==
+*'''Plexin A''' controls axon guidance<ref>PMID:9875845</ref>.
+*'''Plexin B''' regulates Rho GTPase<ref>PMID:12183458</ref>.
+*'''Plexin C''' is the receptor for GPI-anchored semaphorin Sema7A<ref>PMID:10520995</ref>.
-{{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+== Structural highlights ==
-{{#tree:id=OrganizedByTopic|openlevels=0|
-*Plexin A
+*<scene name='46/466532/Cv/4'>Plexin C1 interactions with semaphoric SEMA7A</scene>. Water molecules are shown as red spheres.
+*<scene name='46/466532/Cv/5'>Ca coordination site</scene>.
-**[[3al8]], [[3oky]] – mPLX-A2 + semaphorin-6A – mouse<br />
+==3D structures of plexin==
-**[[4gza]] - mPLX-A2 + semaphorin-3A + neuropilin-1<br />
+[[Plexin 3D structures]]
-**[[3al9]], [[3okt]] – mPLX-A2 extracellular domain<br />
+</StructureSection>
-**[[3ig3]] - mPLX-A3 intracellular domain<br />
-**[[3ryt]] - mPLX-A1 intracellular domain + Ras-related C3 botulinum toxin substrate<br />
-**[[3q3j]] - hPLX-A2  binding domain + Rho-related GTP-binding protein Rho6 – human<br />
-**[[4e74]] - hPLX-A4 Rho GTPase-binding domain
-*Plexin B
-**[[2r2o]] – hPLX-B1 effector domain
-**[[2rex]] - hPLX-B1 effector domain + Rho-related GTP-binding protein Rho6
-**[[2jph]] - hPLX-B1 Rho GTPase-binding domain – NMR<br />
-**[[4e71]] - hPLX-B2 Rho GTPase-binding domain<br />
-**[[3ol2]] - hPLX-B1 + semaphorin 4D
-**[[3sua]], [[3su8]] – hPLX-B1 + RAS-related C3 botulinum toxin substrate
-**[[3hm6]] - hPLX-B1 cytoplasmic domain + peptide
-*Plexin C
-**[[3kuz]] - hPLX-C1 ubiquitin-like domain
-**[[3nvn]], [[3nvq]] – hPLX-C1 + semaphorin 7A
-*Plexin D
-**[[3h6n]] - hPLX-D1 ubiquitin-like domain
-}}
 == References ==
 <references/>
 [[Category:Topic Page]]