Plexin: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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-{{STRUCTURE_3hm6|  PDB=3hm6  | SIZE=400| SCENE= |right|CAPTION=Human plexin-B1 complex with peptide, [[3hm6]] }}
+<StructureSection load='' size='350' side='right' caption='Glycosylated human plexin C1 (magenta) complex with semaphoric SEMA7A (green) and Ca+2 ion (green) (PDB entry [[3nvn]])' scene='46/466532/Cv/1' pspeed='8'>
+'''Plexin''' (PLX) is the receptor for semaphorin<ref>PMID:20877282</ref>.
-'''Plexin''' (PLX) is the receptor for semaphorin.
-==3D structures of plexin==
+*'''Plexin A''' controls axon guidance<ref>PMID:9875845</ref>.
+*'''Plexin B''' regulates Rho GTPase<ref>PMID:12183458</ref>.
+*'''Plexin C''' is the receptor for GPI-anchored semaphorin Sema7A<ref>PMID:10520995</ref>.
-===Plexin A===
+== Structural highlights ==
-[[3al8]], [[3oky]] – mPLX-A2 + semaphorin-6A – mouse
+*<scene name='46/466532/Cv/4'>Plexin C1 interactions with semaphoric SEMA7A</scene>. Water molecules are shown as red spheres.
+*<scene name='46/466532/Cv/5'>Ca coordination site</scene>.
-[[3al9]], [[3okt]] – mPLX-A2 extracellular domain
+==3D structures of plexin==
+[[Plexin 3D structures]]
-[[3q3j]] - hPLX-A2  binding domain + Rho-related GTP-binding protein Rho6 – human
+</StructureSection>
-===Plexin B===
-[[2r2o]] – hPLX-B1 effector domain
-[[2rex]] - hPLX-B1 effector domain + Rho-related GTP-binding protein Rho6
-[[2jph]] - hPLX-B1 Rho GTPase-binding domain – NMR
-[[3ol2]] - hPLX-B1 + semaphorin 4D
-[[3sua]] – hPLX-B1 + RAS-related C3 botulinum toxin substrate
-[[3hm6]] - hPLX-B1 cytoplasmic domain + peptide
-===Plexin C===
-[[3kuz]] - hPLX-C1 ubiquitin-like domain
-[[3nvn]], [[3nvq]] – hPLX-C1 + semaphorin 7A
-===Plexin D===
-[[3h6n]] - hPLX-D1 ubiquitin-like domain
+== References ==
+<references/>
 [[Category:Topic Page]]