5ijv: Difference between revisions
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==Crystal structure of bovine Fab E03== | ==Crystal structure of bovine Fab E03== | ||
<StructureSection load='5ijv' size='340' side='right' caption='[[5ijv]], [[Resolution|resolution]] 2.20Å' scene=''> | <StructureSection load='5ijv' size='340' side='right'caption='[[5ijv]], [[Resolution|resolution]] 2.20Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5ijv]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IJV OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[5ijv]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IJV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5IJV FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ijv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ijv OCA], [https://pdbe.org/5ijv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ijv RCSB], [https://www.ebi.ac.uk/pdbsum/5ijv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ijv ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/Q3T101_BOVIN Q3T101_BOVIN] | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Bos taurus]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Stanfield RL]] | ||
[[Category: | [[Category: Wilson IA]] | ||
Latest revision as of 16:58, 30 August 2023
Crystal structure of bovine Fab E03Crystal structure of bovine Fab E03
Structural highlights
FunctionPublication Abstract from PubMedA subset of bovine antibodies have an exceptionally long third heavy-chain complementarity determining region (CDR H3) that is highly variable in sequence and includes multiple cysteines. These long CDR H3s (up to 69 residues) fold into a long stalk atop which sits a knob domain that is located far from the antibody surface. Three new bovine Fab crystal structures have been determined to decipher the conserved and variable features of ultralong CDR H3s that lead to diversity in antigen recognition. Despite high sequence variability, the stalks adopt a conserved beta-ribbon structure, while the knob regions share a conserved beta-sheet that serves as a scaffold for two connecting loops of variable length and conformation, as well as one conserved disulfide. Variation in patterns and connectivity of the remaining disulfides contribute to the knob structural diversity. The unusual architecture of these ultralong bovine CDR H3s for generating diversity is unique in adaptive immune systems. Conservation and diversity in the ultralong third heavy-chain complementarity-determining region of bovine antibodies.,Stanfield RL, Wilson IA, Smider VV Sci Immunol. 2016 Jul;1(1). pii: aaf7962. Epub 2016 Jul 14. PMID:27574710[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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