5ijn: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''Unreleased structure'''
-The entry 5ijn is ON HOLD
+==Composite structure of the inner ring of the human nuclear pore complex (32 copies of Nup205)==
+<SX load='5ijn' size='340' side='right' viewer='molstar' caption='[[5ijn]], [[Resolution|resolution]] 21.40&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5ijn]] is a 26 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IJN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5IJN FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 21.4&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ijn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ijn OCA], [https://pdbe.org/5ijn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ijn RCSB], [https://www.ebi.ac.uk/pdbsum/5ijn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ijn ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/NU155_HUMAN NU155_HUMAN] Familial atrial fibrillation. The disease is caused by mutations affecting the gene represented in this entry.
+== Function ==
+[https://www.uniprot.org/uniprot/NU155_HUMAN NU155_HUMAN] Essential component of nuclear pore complex. Could be essessential for embryogenesis. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport.[UniProtKB:Q99P88]
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Nuclear pore complexes (NPCs) are 110-megadalton assemblies that mediate nucleocytoplasmic transport. NPCs are built from multiple copies of ~30 different nucleoporins, and understanding how these nucleoporins assemble into the NPC scaffold imposes a formidable challenge. Recently, it has been shown how the Y complex, a prominent NPC module, forms the outer rings of the nuclear pore. However, the organization of the inner ring has remained unknown until now. We used molecular modeling combined with cross-linking mass spectrometry and cryo-electron tomography to obtain a composite structure of the inner ring. This architectural map explains the vast majority of the electron density of the scaffold. We conclude that despite obvious differences in morphology and composition, the higher-order structure of the inner and outer rings is unexpectedly similar.
-Authors: Jan Kosinski, Shyamal Mosalaganti, Alexander von Appen, Martin Beck
+Molecular architecture of the inner ring scaffold of the human nuclear pore complex.,Kosinski J, Mosalaganti S, von Appen A, Teimer R, DiGuilio AL, Wan W, Bui KH, Hagen WJ, Briggs JA, Glavy JS, Hurt E, Beck M Science. 2016 Apr 15;352(6283):363-5. doi: 10.1126/science.aaf0643. PMID:27081072<ref>PMID:27081072</ref>
-Description:
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
-[[Category: Jan Kosinski, Shyamal Mosalaganti, Alexander Von Appen, Martin Beck]]
+<div class="pdbe-citations 5ijn" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Nucleoporin 3D structures|Nucleoporin 3D structures]]
+== References ==
+<references/>
+__TOC__
+</SX>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Beck M]]
+[[Category: Kosinski J]]
+[[Category: Mosalaganti S]]
+[[Category: Von Appen A]]