5ic4: Difference between revisions

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 ==Crystal structure of caspase-3 DEVE peptide complex==
-<StructureSection load='5ic4' size='340' side='right' caption='[[5ic4]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
+<StructureSection load='5ic4' size='340' side='right'caption='[[5ic4]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[5ic4]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IC4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IC4 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5ic4]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IC4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5IC4 FirstGlance]. <br>
-</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MKE:(4S)-4-AMINO-5-OXOHEXANOIC+ACID'>MKE</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5ic6|5ic6]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MKE:(4S)-4-AMINO-5-OXOHEXANOIC+ACID'>MKE</scene></td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-3 Caspase-3], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.56 3.4.22.56] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ic4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ic4 OCA], [https://pdbe.org/5ic4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ic4 RCSB], [https://www.ebi.ac.uk/pdbsum/5ic4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ic4 ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ic4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ic4 OCA], [http://pdbe.org/5ic4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ic4 RCSB], [http://www.ebi.ac.uk/pdbsum/5ic4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ic4 ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/CASP3_HUMAN CASP3_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.<ref>PMID:7596430</ref> <ref>PMID:21357690</ref>
+[https://www.uniprot.org/uniprot/CASP3_HUMAN CASP3_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.<ref>PMID:7596430</ref> <ref>PMID:21357690</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 20: / Line 19: @@
 </div>
 <div class="pdbe-citations 5ic4" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Caspase 3D structures|Caspase 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Caspase-3]]
+[[Category: Homo sapiens]]
-[[Category: Julien, O]]
+[[Category: Large Structures]]
-[[Category: Lee, P S]]
+[[Category: Synthetic construct]]
-[[Category: Rettenmaier, T J]]
+[[Category: Julien O]]
-[[Category: Seaman, J E]]
+[[Category: Lee PS]]
-[[Category: Thomsen, N D]]
+[[Category: Rettenmaier TJ]]
-[[Category: Wells, J A]]
+[[Category: Seaman JE]]
-[[Category: Apoptosis]]
+[[Category: Thomsen ND]]
-[[Category: Hydrolase-hydrolase inhibitor complex]]
+[[Category: Wells JA]]