3egb: Difference between revisions

<StructureSection load='3egb' size='340' side='right'caption='[[3egb]], [[Resolution|resolution]] 3.25&Aring;' scene=''>

<table><tr><td colspan='2'>[[3egb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EGB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EGB FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.25&#8491;</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3egb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3egb OCA], [https://pdbe.org/3egb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3egb RCSB], [https://www.ebi.ac.uk/pdbsum/3egb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3egb ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/PELI2_HUMAN PELI2_HUMAN] E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. May be important for LPS- and IL1B-induced MAP3K7-dependent, but not MAP3K3-dependent, NF-kappa-B activation. Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1.<ref>PMID:12804775</ref> <ref>PMID:12860405</ref> <ref>PMID:17675297</ref> <ref>PMID:17997719</ref> <ref>PMID:22669975</ref>  

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Ferguson KM]]

[[Category: Lin C]]

[[Category: Schmitz KR]]