3egb: Difference between revisions
No edit summary |
No edit summary |
||
| (3 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
==Structure of Pellino2 FHA domain at 3.3 Angstroms resolution.== | ==Structure of Pellino2 FHA domain at 3.3 Angstroms resolution.== | ||
<StructureSection load='3egb' size='340' side='right' caption='[[3egb]], [[Resolution|resolution]] 3.25Å' scene=''> | <StructureSection load='3egb' size='340' side='right'caption='[[3egb]], [[Resolution|resolution]] 3.25Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3egb]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[3egb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EGB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EGB FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.25Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3egb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3egb OCA], [https://pdbe.org/3egb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3egb RCSB], [https://www.ebi.ac.uk/pdbsum/3egb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3egb ProSAT]</span></td></tr> | |||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </table> | ||
<table> | == Function == | ||
[https://www.uniprot.org/uniprot/PELI2_HUMAN PELI2_HUMAN] E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. May be important for LPS- and IL1B-induced MAP3K7-dependent, but not MAP3K3-dependent, NF-kappa-B activation. Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1.<ref>PMID:12804775</ref> <ref>PMID:12860405</ref> <ref>PMID:17675297</ref> <ref>PMID:17997719</ref> <ref>PMID:22669975</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 13: | Line 15: | ||
Pellino proteins contain a cryptic FHA domain that mediates interaction with phosphorylated IRAK1.,Lin CC, Huoh YS, Schmitz KR, Jensen LE, Ferguson KM Structure. 2008 Dec 10;16(12):1806-16. PMID:19081057<ref>PMID:19081057</ref> | Pellino proteins contain a cryptic FHA domain that mediates interaction with phosphorylated IRAK1.,Lin CC, Huoh YS, Schmitz KR, Jensen LE, Ferguson KM Structure. 2008 Dec 10;16(12):1806-16. PMID:19081057<ref>PMID:19081057</ref> | ||
From | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 3egb" style="background-color:#fffaf0;"></div> | |||
== References == | == References == | ||
<references/> | <references/> | ||
| Line 20: | Line 23: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Ferguson KM]] | ||
[[Category: | [[Category: Lin C]] | ||
[[Category: | [[Category: Schmitz KR]] | ||